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Updated: Jun 23, 2026

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
In Vivo Pharmacokinetics, Bio-Distribution and anti-Tumor Activity of Docetaxel-Loaded Folate Targeted Biocompatible
Moloud Kazemi1,2, Jaber Emami2, Farshid Hasanzadeh3
1Nanotechnology Research Center, Medical Basic Research Sciences Institute, Department of Pharmaceutics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
None:
Anti-tumor agent, docetaxel (DTX), was incorporated into novel pre-synthesized pH-triggered folate-targeted polymeric micelles to overcome insufficient drug accumulation at the tumor site and to reduce side effects in healthy tissues. Tumor growth inhibition rate (87.8%), elimination half-life (7.15 h), and tumor targeting efficiency (74.3%) for the targeted micellar formulation were significantly improved compared to those of free DTX (52.14%, 4.98 h, and 52.92% respectively). Overall, the findings of the current study showed that folate-targeted micelle is a potential targeting drug delivery system improving the efficacy of anticancer drugs through selective targeting of tumor tissues.
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