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Related Concept Videos

Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...

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Related Experiment Video

Updated: Jun 23, 2026

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level
09:45

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

Published on: March 14, 2022

Mapping the Cell-Cell Interactions in Cardiovascular Diseases: A Single-Cell Atlas Perspective.

Seungyoon Song1, Cherin Lee2, Hun-Jun Park3,4

  • 1Department of Bioinformatics, Soongsil University, Seoul, Korea.

Korean Circulation Journal
|June 21, 2026
PubMed
Summary
This summary is machine-generated.

Cardiovascular disease (CVD) disrupts vital cell-cell communication, leading to heart damage. Understanding these altered signaling pathways offers new therapeutic targets for cardiovascular pathologies.

Keywords:
Cardiovascular diseasesCell-cell interactionFibroblastMacrophageSingle-cell atlas

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Isolation of Human Primary Valve Cells for In vitro Disease Modeling
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Isolation of Human Primary Valve Cells for In vitro Disease Modeling

Published on: April 16, 2021

Related Experiment Videos

Last Updated: Jun 23, 2026

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level
09:45

Isolation and Profiling of Human Primary Mesenteric Arterial Endothelial Cells at the Transcriptome Level

Published on: March 14, 2022

Isolation of Human Primary Valve Cells for In vitro Disease Modeling
07:31

Isolation of Human Primary Valve Cells for In vitro Disease Modeling

Published on: April 16, 2021

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Systems Biology

Background:

  • Cell-cell interactions are crucial for cardiovascular homeostasis.
  • Dysregulated communication among heart and vascular cells drives cardiovascular disease (CVD) pathogenesis, including inflammation and fibrosis.
  • Recent transcriptomic technologies allow detailed mapping of cellular interactions.

Purpose of the Study:

  • To review major alterations in intercellular communication across cardiovascular pathologies.
  • To highlight the role of disrupted cell crosstalk in cardiomyopathy, myocardial infarction, and heart failure.
  • To provide insights into CVD mechanisms and guide targeted therapy development.

Main Methods:

  • Systematic inference of intercellular communication using ligand-receptor analysis.
  • Construction of detailed cellular atlases of the human heart and vasculature via single-cell and spatial transcriptomics.
  • Summarization of disease-specific alterations in key signaling pathways.

Main Results:

  • Identification of significant changes in cell-cell communication across various cardiovascular pathologies.
  • Uncovering disease-specific alterations in critical signaling pathways.
  • Demonstration of how altered crosstalk among vascular, stromal, and immune cells contributes to adverse cardiac remodeling and dysfunction.

Conclusions:

  • Disrupted intercellular communication networks are central to cardiovascular disease.
  • Understanding these molecular mechanisms offers novel therapeutic strategies for CVD.
  • Targeting cell-cell communication pathways holds promise for restoring cardiovascular health.