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Updated: Jun 23, 2026

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods

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Published on: September 10, 2018

Nanomaterial-Based Strategies to Modulate Placental Dysfunction in Preeclampsia.

Yizi Wang¹, Sishi Liu¹, Ying Shen¹

¹Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

Comprehensive Physiology

|June 22, 2026

Summary

This summary is machine-generated.

Preeclampsia, a pregnancy disorder, stems from placental issues. Nanomedicine offers targeted therapies to treat the placenta, improving outcomes for preeclampsia (PE) patients.

Keywords:

nanomedicine oxidative stress placental dysfunction placenta‐targeted delivery preeclampsia

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Published on: June 18, 2013

Area of Science:

Obstetrics and Gynecology
Nanomedicine
Maternal-Fetal Medicine

Background:

Preeclampsia (PE) is a pregnancy-specific disorder causing hypertension and multi-organ dysfunction, primarily due to placental abnormalities.
Pathological features include impaired trophoblast invasion, defective spiral artery remodeling, angiogenic imbalance, oxidative stress, and inflammation.
Current management is supportive, necessitating novel therapies targeting the placenta with minimal fetal risk.

Purpose of the Study:

To review the pathological mechanisms of placental dysfunction in preeclampsia.
To discuss the design principles for safe and effective pregnancy nanomaterials.
To evaluate emerging nanomedicine strategies for preeclampsia treatment.

Main Methods:

Review of current literature on preeclampsia pathophysiology and nanomedicine applications.
Analysis of nanomaterial design principles for placental targeting and safety.
Evaluation of preclinical models and therapeutic strategies using nanomedicine.

Main Results:

Nanomaterials enable targeted delivery to the placenta, controlled drug release, and modulation of pathogenic pathways.
Placenta-targeted nanomedicine can attenuate oxidative stress, suppress inflammation, and restore angiogenic balance.
Emerging strategies show potential in regulating placental gene expression and improving the microenvironment.

Conclusions:

Nanomedicine presents a promising avenue for developing mechanism-based therapies for preeclampsia.
Targeting placental dysfunction with nanomedicine offers a strategy to improve maternal and fetal outcomes.
Further research and addressing translational challenges are crucial for advancing precision nanomedicine for preeclampsia.