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Updated: Jun 23, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
Published on: February 8, 2020
The Heterogeneity of B Cells Potentially Contributes to Metastasis of Clear Cell Renal Cell Carcinomas
Yuanhong Chen1,2, Chun Guo3, Shaoang Huang4,5
1Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise, China.
Background:
Clear cell renal cell carcinoma (ccRCC) exhibits extensive immune infiltration, yet the influence of immunological heterogeneity on clinical outcomes remains poorly elucidated.
Objectives:
Addressing the formidable challenge of metastasis suppression in ccRCC treatment.
Methods:
Use scRNA-seq analysis and immunofluorescent imaging to categorize B cells into sub-clusters based on distinct gene expression profiles.
Results:
Identify two significant B cell subpopulations, B cell (HLA-DRA) and B cell (FKBP11); show the upregulation of six genes (DERL3, FKBP11, MZB1, TNFSF13B, MYO9B, and ACAP1) in infiltrating B lymphocytes associated with poor prognosis of ccRCC; find that B cell (HLA-DRA) displays a noteworthy association with ccRCC metastasis and demonstrates relevance to tumor immunity across diverse cancers.
Conclusions:
The heterogeneity within B-cell subpopulations may substantially contribute to the metastatic potential of clear cell renal cell carcinoma. The findings provide insights into targeted interventions and improved clinical outcomes.
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