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Published on: June 10, 2025
Association Between Neutrophil-Percentage-To-Albumin Ratio Level and Heart Failure in Hypertensive Population
Mingchen Sun1, Zhiyu Li1, Zihan Zhou1
1College of Medicine, Jishou University, Jishou, Hunan, China, jsu.edu.cn.
International Journal of Hypertension
|June 22, 2026
Summary
The neutrophil-to-albumin ratio (NPAR) is a potential biomarker for heart failure (HF) in hypertensive patients. Higher NPAR levels are independently associated with increased odds of HF, suggesting its utility in risk stratification.
Area of Science:
- Cardiovascular Pathology
- Biomarker Discovery
- Systemic Inflammation
Background:
- Neutrophil-to-albumin ratio (NPAR) is a novel prognostic biomarker for cardiovascular pathology.
- NPAR is gaining interest as a marker of systemic inflammation.
- Heart failure (HF) in hypertensive patients is a significant clinical concern.
Purpose of the Study:
- To investigate the association between NPAR and HF prevalence in hypertensive adults.
- To explore NPAR as a potential prognostic biomarker for HF risk stratification.
- To analyze cross-sectional data for NPAR-HF relationships.
Main Methods:
- Cross-sectional analysis of NHANES 2017-2020 data.
- Inclusion of 3045 hypertensive adults.
- Multivariable logistic regression with comprehensive covariate adjustment.
Main Results:
- The prevalence of HF in the hypertensive cohort was 6.27%.
- Elevated NPAR was independently associated with higher odds of HF (OR=1.17, p<0.001).
- NPAR demonstrated acceptable discriminatory ability for HF (AUC=0.649).
Conclusions:
- NPAR may serve as an accessible and cost-effective HF risk stratification marker in hypertensive individuals.
- Findings suggest NPAR's independent association with HF prevalence.
- Further research may validate NPAR in cardiovascular risk assessment.
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