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Updated: Jun 23, 2026

Hollow Fiber Bioreactors for In Vivo-like Mammalian Tissue Culture
Published on: May 26, 2016
Use of hollow fiber systems to model treatment of infections: A practical guide
Jelmer Raaijmakers1, Fernando Sanz-García2, Zahra Sadouki3
1Radboud Centre for Infectious Diseases, Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, the Netherlands.
Abstract:
This EPASG-endorsed consensus report provides practical and standardized guidance for the use of hollow fiber systems (HFSs) in modeling antimicrobial treatment of bacterial infections. An HFS allows the simulation of dynamic pharmacokinetic (PK) profiles and bacterial responses over extended time periods, making it highly suited for PK/pharmacodynamic (PD) studies. This document serves as a foundational reference for researchers using HFS to evaluate antimicrobial efficacy, optimize dosing regimens, and support translational research in infectious diseases.
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