Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative population genomics reveals adaptive convergence in two Drosophila species across global environments.

Cell reports·2026
Same author

Revealing the Latent Structure of the Oral Behaviours Checklist: Integrating Bayesian Factor Analysis and Network Analysis.

Journal of oral rehabilitation·2026
Same author

Development of a multi-epitope mRNA vaccine targeting tumor-associated antigens for esophageal squamous cell carcinoma.

NPJ vaccines·2026
Same author

Development and validation of the short form OHIP-TMD (SF-OHIP-TMD): a four-factor eight-item scale for assessing oral health impact in temporomandibular disorders.

Clinical oral investigations·2026
Same author

Four-Dimensional Impact of Oral Behaviours on Oral Health-Related Quality of Life Across TMD Subtypes: A Parallel Multivariate Exploration.

Journal of oral rehabilitation·2026
Same author

Breakthroughs in HBV-related HCC Therapy: The Unmatched Potential of Immune Checkpoint Inhibitors.

Current treatment options in oncology·2026
Same journal

Delivery of TCM Monomers Using Blood Cell Membrane Coated Biomimetic Nanoparticles to Target CVD.

International journal of nanomedicine·2026
Same journal

Mechanism-Guided Nanoengineered Therapeutic Peptides for Bone Healing.

International journal of nanomedicine·2026
Same journal

MRI-Guided Magnetic Micro/Nanorobots for Precision Neurotherapeutics: From Intelligent Navigation and BBB Penetration to Clinical Translation.

International journal of nanomedicine·2026
Same journal

EGCG-Building Nanocarriers for Multitasking Drug Delivery: Design Principles, Therapeutic Opportunities, and Translational Challenges.

International journal of nanomedicine·2026
Same journal

Chitosan Oligosaccharide-Functionalized Ruthenium-Curcumin Nanodots for Targeted Therapy of Acute Kidney Injury.

International journal of nanomedicine·2026
Same journal

Magnetic Nanoparticles as a Theranostic Platform in Brain Tumor Treatment: Surmounting the Bench-to-Bedside Barriers.

International journal of nanomedicine·2026
See all related articles

Related Experiment Video

Updated: Jun 23, 2026

Fabricating Highly Open Porous Microspheres (HOPMs) via Microfluidic Technology
05:21

Fabricating Highly Open Porous Microspheres (HOPMs) via Microfluidic Technology

Published on: May 16, 2022

How PLGA Microspheres are Emerging as a Key Drug Delivery System.

Sai Qian1,2,3, Lan Ma1,2, Chenlu Liu1,2

  • 1Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, Hubei, 443000, People's Republic of China.

International Journal of Nanomedicine
|June 22, 2026
PubMed
Summary
This summary is machine-generated.

Poly(lactic-co-glycolic acid) (PLGA) microspheres offer tunable drug delivery. This review details how PLGA material properties and fabrication methods impact drug release for clinical applications.

Keywords:
PLGA microspheresclinical translationdrug delivery systemssustained release kinetics

More Related Videos

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
12:48

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

Preparation of Cross-Linked Sodium Alginate Microspheres with Different Metal Ions Using the Microfluidic Electrospray Technology
07:24

Preparation of Cross-Linked Sodium Alginate Microspheres with Different Metal Ions Using the Microfluidic Electrospray Technology

Published on: June 7, 2024

Related Experiment Videos

Last Updated: Jun 23, 2026

Fabricating Highly Open Porous Microspheres (HOPMs) via Microfluidic Technology
05:21

Fabricating Highly Open Porous Microspheres (HOPMs) via Microfluidic Technology

Published on: May 16, 2022

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
12:48

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

Preparation of Cross-Linked Sodium Alginate Microspheres with Different Metal Ions Using the Microfluidic Electrospray Technology
07:24

Preparation of Cross-Linked Sodium Alginate Microspheres with Different Metal Ions Using the Microfluidic Electrospray Technology

Published on: June 7, 2024

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Polymer Chemistry

Background:

  • Poly(lactic-co-glycolic acid) (PLGA) microspheres are a clinically validated technology for sustained and controlled drug release.
  • These microspheres enable reduced dosing frequency due to their tunable degradation properties.

Purpose of the Study:

  • To critically review PLGA microsphere technology, bridging materials science principles with clinical translation.
  • To examine the influence of molecular parameters and fabrication methods on PLGA microsphere performance.

Main Methods:

  • Literature review and critical appraisal of existing studies on PLGA microsphere technology.
  • Analysis of material properties (molecular weight, ratio, terminal groups) and fabrication techniques (emulsion-solvent evaporation, spray drying, etc.).
  • Discussion of release mechanisms (diffusion, swelling, erosion) and strategies to control drug release kinetics.

Main Results:

  • PLGA molecular parameters significantly affect degradation and drug release profiles.
  • Fabrication methods offer varying degrees of control over particle characteristics, encapsulation efficiency, and scalability.
  • Strategies exist to mitigate burst release and optimize in vivo pharmacokinetics.

Conclusions:

  • PLGA microspheres represent a versatile platform with ongoing advancements in oncology and vaccine delivery.
  • Addressing manufacturing and regulatory challenges is crucial for broader clinical adoption.
  • Future directions include stimuli-responsive systems and AI-driven formulation optimization.