Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comments on "Preventive Effect of Helicobacter pylori Treatment on Gastric Cancer Incidence and Mortality: A Korean Population Study".

Gastroenterology·2025
Same author

TPF regimen improves conversion surgery and short-term survival in patients with locally unresectable advanced gastric cancer.

American journal of translational research·2025
Same author

Effect of the Microstructure of Carbon Supports on the Oxygen Reduction Properties of the Loaded Non-Noble Metal Catalysts.

Nanomaterials (Basel, Switzerland)·2025
Same author

TEA domain transcription factor 3 suppresses aortic and left ventricular remodeling via transcriptional activation of PDZ domain containing 1.

Biochemical pharmacology·2025
Same author

Prospects and challenges of salivary gland tissue engineering in Sjögren's syndrome.

Expert reviews in molecular medicine·2025
Same author

Correction: Overexpression of Nrf2 in bone marrow mesenchymal stem cells promotes B-cell acute lymphoblastic leukemia cells invasion and extramedullary organ infiltration through stimulation of the SDF-1/CXCR4 axis.

Frontiers in pharmacology·2025
Same journal

Advances in the Targeted Drug Delivery System for Renal Fibrosis.

International journal of nanomedicine·2026
Same journal

Nanostructured Lipid Carriers Co-Loaded with Doxycycline, Gentamicin, and Thymol for Enhanced Intracellular Antibacterial Activity Against <i>Brucella melitensis</i>.

International journal of nanomedicine·2026
Same journal

Cyclam-Modified Polyethyleneimine for Simultaneous TGFβ siRNA Delivery and CXCR4 Inhibition for the Treatment of CCl<sub>4</sub>-Induced Liver Fibrosis [Retraction].

International journal of nanomedicine·2026
Same journal

Comparable Efficacy of Chitosan/miR-200b-3p and Lipofectamine/miR-200b-3p Delivered by Pluronic F127 Hydrogel to Facilitate Diabetic Wound Healing.

International journal of nanomedicine·2026
Same journal

Reprogramming Metabolism and Immunity: Nanotechnology's Promise for Hepatocellular Carcinoma Precision Therapy.

International journal of nanomedicine·2026
Same journal

Glucan-Based Nanoparticles Empower Precision Cancer Immunotherapy: Design Strategies, Immune Reprogramming Mechanisms, and Clinical Translation Prospects.

International journal of nanomedicine·2026
See all related articles
  1. Home
  3. Nanomedicine Strategies For Rheumatoid Arthritis: Precision Delivery And Immune Microenvironment Modulation.
  1. Home
  3. Nanomedicine Strategies For Rheumatoid Arthritis: Precision Delivery And Immune Microenvironment Modulation.

Related Experiment Video

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Nanomedicine Strategies for Rheumatoid Arthritis: Precision Delivery and Immune Microenvironment Modulation.

Qian He1, Jinming Xing2, Jie Kang2

  • 1Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, Shanxi, People's Republic of China.

International Journal of Nanomedicine
|June 22, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Nanomedicine offers advanced solutions for rheumatoid arthritis (RA) by enabling precise drug delivery and remodeling the immune microenvironment. This approach targets inflammation and joint destruction more effectively than traditional treatments.

Keywords:
immune microenvironmentnanomaterialsrheumatoid arthritistargeted deliverytheranostics

Related Experiment Videos

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
07:37

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Area of Science:

  • Nanomedicine
  • Immunology
  • Rheumatology

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease causing joint inflammation and destruction.
  • Conventional drugs for RA have limitations in targeting, toxicity, and immune modulation.
  • Nanomedicine presents a promising avenue to overcome these therapeutic challenges.

Purpose of the Study:

  • To review the application of advanced nano-platforms for rheumatoid arthritis (RA) management.
  • To highlight the dual roles of nanomedicine in precision drug delivery and immune microenvironment remodeling.
  • To discuss multifunctional nanomaterials for RA theranostics.

Main Methods:

  • Comprehensive review of current literature on nanomedicine in RA.
  • Analysis of nano-platforms with dual therapeutic functions.
  • Examination of nanomaterials for reactive oxygen species scavenging, hypoxia mitigation, and immune cell reprogramming.

    • Main Results:

    • Multifunctional nanomaterials enable precise drug transport in RA.
    • Nanomedicine actively regulates pathological processes by scavenging ROS, mitigating hypoxia, and reprogramming immune cells.
    • Integrated diagnostic and therapeutic functions in nanomaterial systems advance RA theranostics.

    Conclusions:

    • Nanomedicine holds transformative potential for RA treatment through precision delivery and immune modulation.
    • Intelligent nanomedicine offers a path towards improved RA theranostics.
    • Further research and clinical translation are needed for intelligent RA nanomedicine development.