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Updated: Jun 23, 2026
07:37
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
Nanomedicine Strategies for Rheumatoid Arthritis: Precision Delivery and Immune Microenvironment Modulation
Qian He1, Jinming Xing2, Jie Kang2
1Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, Shanxi, People's Republic of China.
International Journal of Nanomedicine
|June 22, 2026
Summary
Nanomedicine offers advanced solutions for rheumatoid arthritis (RA) by enabling precise drug delivery and remodeling the immune microenvironment. This approach targets inflammation and joint destruction more effectively than traditional treatments.
Area of Science:
- Nanomedicine
- Immunology
- Rheumatology
Background:
- Rheumatoid arthritis (RA) is a chronic autoimmune disease causing joint inflammation and destruction.
- Conventional drugs for RA have limitations in targeting, toxicity, and immune modulation.
- Nanomedicine presents a promising avenue to overcome these therapeutic challenges.
Purpose of the Study:
- To review the application of advanced nano-platforms for rheumatoid arthritis (RA) management.
- To highlight the dual roles of nanomedicine in precision drug delivery and immune microenvironment remodeling.
- To discuss multifunctional nanomaterials for RA theranostics.
Main Methods:
- Comprehensive review of current literature on nanomedicine in RA.
- Analysis of nano-platforms with dual therapeutic functions.
- Examination of nanomaterials for reactive oxygen species scavenging, hypoxia mitigation, and immune cell reprogramming.
Main Results:
- Multifunctional nanomaterials enable precise drug transport in RA.
- Nanomedicine actively regulates pathological processes by scavenging ROS, mitigating hypoxia, and reprogramming immune cells.
- Integrated diagnostic and therapeutic functions in nanomaterial systems advance RA theranostics.
Conclusions:
- Nanomedicine holds transformative potential for RA treatment through precision delivery and immune modulation.
- Intelligent nanomedicine offers a path towards improved RA theranostics.
- Further research and clinical translation are needed for intelligent RA nanomedicine development.
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