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Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
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Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

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The correlation between the atherogenic index of plasma and aortic valve calcification in the general population: a

Bolun Jiao1, Rui Yu2, Lei Li3

  • 1The First Clinical Medical College, Xinjiang Medical University, Urumqi, Xinjiang, China.

Frontiers in Endocrinology
|June 22, 2026
PubMed

Insights

Higher atherogenic index of plasma (AIP) significantly increases the risk of aortic valve calcification (AVC). AIP is a valuable biomarker for predicting AVC risk, outperforming traditional markers like triglycerides and cholesterol.

Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Clinical Diagnostics

Background:

  • Aortic valve calcification (AVC) is a growing concern in cardiovascular health.
  • Identifying reliable biomarkers for AVC risk is crucial for early intervention.
  • The atherogenic index of plasma (AIP) is a lipid-based marker that warrants investigation for its association with AVC.

Purpose of the Study:

  • To investigate the correlation between the atherogenic index of plasma (AIP) and the risk of developing aortic valve calcification (AVC).
  • To evaluate the diagnostic value of AIP as a biomarker for AVC compared to traditional lipid parameters.

Main Methods:

  • A retrospective cohort study involving 1,752 participants was conducted.
  • Participants were analyzed using multivariate logistic regression, subgroup, sensitivity, and ROC curve analyses.
  • The association between AIP levels and AVC incidence was assessed, with adjustments for potential confounders.

Main Results:

  • Each 1-unit increase in AIP was linked to a 146.0% higher risk of AVC (OR = 2.460).
  • Higher AIP quartiles demonstrated significantly increased AVC risk compared to the lowest quartile (Q2: 1.623-fold, Q3: 2.405-fold, Q4: 2.319-fold).
  • AIP showed moderate diagnostic value for AVC risk (AUC = 0.760), outperforming triglycerides and total cholesterol.

Conclusions:

  • Elevated AIP levels are significantly associated with an increased risk of AVC.
  • AIP demonstrates considerable clinical utility as an associative biomarker for AVC.
  • AIP may serve as a more effective predictor of AVC risk than conventional lipid profiles.
Abstract

Keywords:
aortic valve calcificationatherogenic index of plasmageneral populationreceiver operating characteristic curvesensitivity analysis

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