Related Experiment Video
Updated: Jun 23, 2026

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
Efficacy and safety analysis of double plasma molecular adsorption system plus plasma exchange for treating
Yali Cheng1, Yanyan Ren1, Jiahao Li1
1Zhoukou Central Hospital Affiliated to Henan Medical University Zhoukou 466000, Henan, China.
Objective:
This retrospective study aimed to evaluate the efficacy and safety of the double plasma molecular adsorption system (DPMAS) plus plasma exchange (PE) in treating acute-on-chronic liver failure (ACLF).
Methods:
A total of 200 ACLF patients were enrolled and divided into two groups: the control group received PE therapy alone, while the observation group received DPMAS in addition to PE. Clinical data were collected from both groups, including treatment efficacy, safety, clinical indicators, symptom improvement, liver function, coagulation function, electrolytes, nutritional status, inflammatory markers, and short-term prognosis (assessed by the Model for End-Stage Liver Disease (MELD) score), and 12-week survival rate.
Results:
Compared to the control group, the observation group showed notably higher total effective rates and greater symptom improvement at 4 weeks post-treatment. The fluctuation range of all coagulation indices after treatment was smaller in the observation group relative to the control group. Moreover, after treatment, the observation group showed a smaller number of PE treatments, less plasma volume used, and shorter length of hospital stay compared to the control group, as well as lower liver function indicator levels and MELD scores.
Conclusion:
DPMAS combined with PE therapy demonstrates definite efficacy in ACLF treatment without increasing side effects.
Related Concept Videos
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug
