Related Experiment Video
Updated: Jun 23, 2026
Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
Expression of serum inflammatory markers in colorectal cancer and their relationship with clinical pathological
1Department of General Surgery, Affiliated Hospital of Zunyi Medical University Zunyi 563000, Guizhou, China.
Objective:
This retrospective study primarily aimed to measure serum inflammatory markers in colorectal cancer and examine their relationship with clinical pathological characteristics.
Methods:
A total of 147 CRC patients (assigned to the training group (103 cases) or the validation group (44 cases) at a 7:3 ratio) and 100 control participants were enrolled. Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) levels in serum were compared between the training and control groups. The diagnostic value of these markers for CRC and their relationship with the clinical pathological characteristics of CRC patients were evaluated. The correlations among inflammatory markers and their correlations with tumor markers were analyzed. Finally, the clinical data of the training and validation groups were compared, and the diagnostic value of each inflammatory marker was verified in the validation group.
Results:
Inflammatory markers were notably elevated in the CRC group and showed significant correlations with Tumor-Node-Metastasis (TNM) staging, lymph node metastasis (LNM), and tumor diameter. Additionally, all these three markers showed positive correlations with each other and with tumor markers. Each inflammatory marker demonstrated certain diagnostic efficacy for clinical pathological characteristics. Specifically, IL-6 exhibited outstanding efficacy for LNM (area under the curve (AUC) = 0.798), and CRP performed best in differentiating tumor diameter (AUC = 0.730). Moreover, the AUC values in the validation group were comparable to those in the training group.
Results:
IL-6, TNF-α, and CRP may serve as potential tools to assist in the assessment of disease progression and metastatic potential in colorectal cancer.
Related Concept Videos
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
01:20Inflammatory Bowel Disease II: Ulcerative Colitis
01:25Inflammatory Bowel Disease III: Crohn's Disease
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:30Serum Laboratory Studies, Stool Test, Breath Test