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Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
11:14

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

Co-infection with hepatitis B and human immunodeficiency virus: epidemiology, pathogenesis, and treatment

Yaozu He1,2, Weiyin Lin1,2, Fei Gu1,2

  • 1Guangzhou Medical Research Institute of Infectious Diseases, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou 510060, China.

Infectious Diseases & Immunity
|June 22, 2026
PubMed

Insights

Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) co-infection accelerates liver disease progression, increasing risks for cirrhosis and liver cancer. Regular monitoring and treatment are crucial for managing liver health in coinfected patients.

Area of Science:

  • Hepatology
  • Virology
  • Immunology

Background:

  • Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) co-infection is prevalent due to shared transmission routes.
  • HIV exacerbates chronic HBV infection, leading to increased viral load, cirrhosis, and hepatocellular carcinoma.
  • Liver disease is a major cause of mortality in HIV-infected individuals, even with antiretroviral therapy.

Purpose of the Study:

  • To review the natural history and pathogenesis of liver disease in HBV/HIV co-infection.
  • To examine current treatment strategies for HBV in HIV-positive patients.
  • To assess treatment outcomes in individuals with HBV/HIV co-infection.

Main Methods:

  • Literature review of studies on HBV/HIV co-infection.
  • Analysis of disease progression and pathogenesis.
  • Evaluation of therapeutic interventions and outcomes.

Main Results:

  • Co-infection significantly impacts liver disease progression.
  • Antiretroviral therapy for HIV does not fully prevent HBV-related liver complications.
  • Effective management requires integrated treatment approaches.

Conclusions:

  • Screening and diligent follow-up are essential for monitoring liver disease in HBV/HIV co-infected patients.
  • Optimized treatment strategies are needed to improve outcomes.
  • Further research into long-term management is warranted.

Keywords:
Antiretroviral therapyFunctional cureHIVHepatitis B virusPathogenesis

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