Vanishing liver metastases in pancreatic cancer: A case report

Metastatic pancreatic cancer carries a poor prognosis, with palliative chemotherapy offering limited survival benefit and conversion to resectability considered rare. The present study reports the case of a 60-year-old woman with pancreatic adenocarcinoma and extensive liver metastases treated with palliative FOLFIRINOX, achieving complete radiological disappearance of hepatic disease and sustained control of the primary tumour. After a treatment pause and subsequent reinitiation of chemotherapy for local progression, the liver metastases remained absent. At 32 months post-diagnosis, the patient underwent pancreatic resection with negative margins and remains alive and free from hepatic recurrence 84 months from diagnosis. This case highlights that select patients may achieve long-term survival through individualized, multimodal treatment strategies.