Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...

Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Click-polymerized polyenamine membranes for efficient lithium extraction.

Nature communications·2026

Same author

Synthesis of Uniform 6-Armchair Graphene Nanoribbons and Their Isotope and Nitrogen-Doped Derivatives.

Angewandte Chemie (International ed. in English)·2026

Same author

Global, regional, and national burden of pathogen-attributable infectious diseases in children by age and sex, 1990-2021: a systematic analysis.

Infection·2026

Same author

Harnessing Corrosion in A P(VDF-TrFE)/Mg Composite for Dynamic Passivation and Osteoimmunomodulation.

Advanced materials (Deerfield Beach, Fla.)·2026

Same author

Global, regional, and national burden of chronic obstructive pulmonary disease and asthma from 1990 to present: risk attributions and projections to 2050.

Internal and emergency medicine·2026

Same author

Cost-Effectiveness of Initiating Colorectal Cancer Screening at Age 40 Among Average-Risk Individuals in China.

International journal of cancer·2026

Search research articles

Related Experiment Video

Updated: Jun 23, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

The association between systemic immune-inflammation index and post-stroke depression: a meta-analysis.

Wendi Zhang¹, Geng Chang¹, Zhen Mu²

¹Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.

Frontiers in Psychiatry

|June 22, 2026

Summary

High systemic immune-inflammation index (SII) is linked to a doubled risk of post-stroke depression (PSD). This inflammatory biomarker may help identify stroke patients prone to developing depression early.

Keywords:

depression meta-analysis risk factor stroke systemic immune-inflammation index

More Related Videos

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

Related Experiment Videos

Last Updated: Jun 23, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

Area of Science:

Neuroscience
Immunology
Clinical Medicine

Background:

Post-stroke depression (PSD) is a frequent complication impacting stroke recovery.
The systemic immune-inflammation index (SII) reflects inflammatory status but its link to PSD is unclear.

Purpose of the Study:

To investigate the association between SII and the risk of developing PSD.
To clarify the role of SII as a potential biomarker for PSD.

Main Methods:

A meta-analysis of observational studies was conducted.
Data from 7 studies including 2,780 adult stroke patients were pooled.
Random-effects models were used to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs).

Main Results:

High SII at admission was significantly associated with an increased risk of PSD (OR = 2.14, 95% CI: 1.74-2.64).
Sensitivity analyses confirmed the robustness of the findings.
The association was consistent across various subgroups and study characteristics.

Conclusions:

Elevated SII may independently increase the risk of PSD by approximately twofold.
SII could serve as a practical inflammatory biomarker for early PSD risk identification in stroke patients.