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Published on: May 22, 2019
The association between systemic immune-inflammation index and post-stroke depression: a meta-analysis
Wendi Zhang1, Geng Chang1, Zhen Mu2
1Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Frontiers in Psychiatry
|June 22, 2026
Summary
High systemic immune-inflammation index (SII) is linked to a doubled risk of post-stroke depression (PSD). This inflammatory biomarker may help identify stroke patients prone to developing depression early.
Area of Science:
- Neuroscience
- Immunology
- Clinical Medicine
Background:
- Post-stroke depression (PSD) is a frequent complication impacting stroke recovery.
- The systemic immune-inflammation index (SII) reflects inflammatory status but its link to PSD is unclear.
Purpose of the Study:
- To investigate the association between SII and the risk of developing PSD.
- To clarify the role of SII as a potential biomarker for PSD.
Main Methods:
- A meta-analysis of observational studies was conducted.
- Data from 7 studies including 2,780 adult stroke patients were pooled.
- Random-effects models were used to calculate pooled odds ratios (ORs) and 95% confidence intervals (CIs).
Main Results:
- High SII at admission was significantly associated with an increased risk of PSD (OR = 2.14, 95% CI: 1.74-2.64).
- Sensitivity analyses confirmed the robustness of the findings.
- The association was consistent across various subgroups and study characteristics.
Conclusions:
- Elevated SII may independently increase the risk of PSD by approximately twofold.
- SII could serve as a practical inflammatory biomarker for early PSD risk identification in stroke patients.
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