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Published on: October 16, 2013
Comparing IL-6 and IL-10 Serum Levels and Changes Using Propofol and Remimazolam: A Prospective Randomized Controlled
Donghyo Kim1, Hyoungoh Yang1, Jihyun An1
1Anesthesiology, Daegu Fatima Hospital, Daegu, KOR.
Cureus
|June 22, 2026
Summary
This study found no significant differences in interleukin-6 (IL-6) or interleukin-10 (IL-10) levels between remimazolam and propofol anesthesia. However, remimazolam was associated with higher intraoperative BIS values and lower postoperative pain, warranting further investigation.
Area of Science:
- Anesthesiology
- Immunology
- Surgical Care
Background:
- Surgical stress impacts cytokine levels, influencing inflammatory and immune responses.
- Interleukin-6 (IL-6) and Interleukin-10 (IL-10) are key players in perioperative inflammation.
- General anesthetics affect immune function; propofol is known to decrease IL-6, IL-10, and TNF-α.
Purpose of the Study:
- To compare the effects of remimazolam versus propofol on perioperative inflammatory cytokines (IL-6, IL-10, TNF-α).
- To evaluate hemodynamic variables during anesthesia with remimazolam and propofol.
- To assess postoperative analgesic requirements in patients receiving remimazolam or propofol.
Main Methods:
- A prospective randomized study involving 46 patients undergoing laparoscopic gynecological surgery.
- Blood samples were collected at four time points (pre-anesthesia, end of surgery, 1.5h post-op, 24h post-op).
- Serum IL-6, IL-10, and TNF-α levels were measured; TNF-α was below detectable limits.
Main Results:
- No significant intergroup differences in IL-6, IL-10, or IL-6/IL-10 ratio were observed.
- The remimazolam group showed higher intraoperative Bispectral Index (BIS), heart rate, and blood pressure.
- The propofol group required more postoperative oxycodone.
Conclusions:
- Perioperative IL-6 and IL-10 responses did not differ significantly between remimazolam and propofol.
- Higher BIS values in the remimazolam group suggest potential differences in anesthetic depth, requiring cautious interpretation.
- Further large-scale studies are needed to clarify the immunomodulatory and hemodynamic effects of remimazolam.
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