Related Experiment Video
Updated: Jun 23, 2026

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
Published on: April 16, 2019
Low-Grade Trichoblastic Carcinoma of the Scalp: A Rare Case Managed With Adjuvant Radiotherapy
Jorge A Valdivieso1, Rebecca K Hicks2
1Internal Medicine-Pediatrics, Marshall University Joan C. Edwards School of Medicine, Huntington, USA.
Abstract:
Trichoblastic carcinoma (TBC) is a rare malignant adnexal tumor originating from follicular germinative cells. It can resemble basal cell carcinoma (BCC) both clinically and histologically, often leading to diagnostic and therapeutic challenges. We report a 44-year-old male patient who presented with a recurrent exophytic scalp lesion initially diagnosed as pilomatrixoma. Following wide local excision, histopathologic analysis revealed a low-grade TBC with narrow margins. Due to the close proximity of tumor cells to the surgical margins, the patient underwent adjuvant volumetric modulated arc therapy (VMAT) to a total dose of 50 Gy in 20 fractions. This case underscores the importance of accurate histopathologic differentiation between TBC and BCC. Surgical excision with adequate margins remains the treatment of choice, while adjuvant radiotherapy may be warranted in cases with narrow or positive margins to prevent recurrence.
Related Concept Videos
Treatment Resistant Cancers
Treatment Resistent Cancers
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
