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Hairy Cell Leukemia: A Rare Differential for an Infiltrative Pancreatic Mass
Sarah Ibrahim1, Sana Rabeeah2, Nishant Aggarwal3
1Oakland University, William Beaumont School of Medicine, Rochester, MI.
ACG Case Reports Journal
|June 22, 2026
Summary
Hairy cell leukemia (HCL) can rarely manifest as a pancreatic mass. This case shows recurrent HCL presenting as a pancreatic tail lesion, mimicking malignancy.
Area of Science:
- Hematology
- Oncology
- Gastroenterology
Background:
- Hairy cell leukemia (HCL) is a rare B-cell neoplasm.
- HCL typically presents with pancytopenia, but extranodal involvement can occur.
- Pancreatic mass presentation of HCL is exceptionally uncommon.
