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Related Experiment Video

Updated: Jun 23, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
19:15

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Neonatal Brain Network Integration Trajectories Predict Neurodevelopment in Congenital Heart Disease.

Lauren Harasymiw1, Amy Kuang2, Duan Xu2

  • 1Department of Pediatrics, University of California San Francisco.

Medrxiv : the Preprint Server for Health Sciences
|June 22, 2026
PubMed
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Longitudinal brain network development in infants with critical congenital heart disease predicts cognitive, language, and motor outcomes. Early network growth is a potential biomarker for neurodevelopmental risk and resilience.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Pediatric Cardiology

Background:

  • Infants with critical congenital heart disease (CHD) face heightened risks for developmental impairments.
  • Abnormal brain development is a significant concern in this vulnerable population.

Purpose of the Study:

  • To investigate the association between perioperative whole-brain network development trajectories and neurodevelopmental outcomes in early childhood.
  • To determine if longitudinal brain network development predicts cognitive, language, and motor skills.

Main Methods:

  • Prospective longitudinal cohort study of 97 neonates with critical CHD.
  • Brain MRI with diffusion imaging to derive whole-brain network measures from structural connectomes.
  • Neurodevelopmental assessment using Bayley Scales of Infant and Toddler Development between 1 and 4 years.

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Last Updated: Jun 23, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
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Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

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Main Results:

  • Slower perioperative growth in global efficiency (network integration) was linked to white matter injury, not cardiac physiology subtype.
  • Increased perioperative global efficiency growth correlated with higher cognitive, language, and motor scores.
  • Each 1-SD increase in global efficiency trajectory predicted an 8.2-point increase in cognitive scores, independent of other factors.

Conclusions:

  • Longitudinal whole-brain network development in infants with critical CHD is associated with neurodevelopment across multiple domains.
  • Early network development serves as a potential biomarker for identifying neurodevelopmental risk and resilience.
  • Findings support future risk stratification and targeted interventions for infants with critical CHD.