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Related Experiment Video

Updated: Jun 23, 2026

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
09:48

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

Allostatic Load in Endometrial Cancer Disparities.

Ganga S Bey, Mikayla Borthwick Bowen, Sirui Wu

    Medrxiv : the Preprint Server for Health Sciences
    |June 22, 2026
    PubMed
    Summary
    This summary is machine-generated.

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    Allostatic load (AL) scores show differences across racial groups in endometrial cancer patients. Higher AL is linked to poorer survival in low-grade tumors, while intermediate AL is worst for high-grade tumors, highlighting disparities.

    Area of Science:

    • Oncology
    • Public Health
    • Physiology

    Background:

    • Endometrial cancer incidence and mortality are rising, especially in Black women and for aggressive subtypes.
    • Allostatic load (AL), a measure of physiological dysregulation, varies by race and tumor subtype in other cancers.
    • The relationship between AL, obesity, and clinical outcomes in endometrial cancer is not well understood.

    Purpose of the Study:

    • To assess the performance of AL scoring in endometrial cancer patients.
    • To examine associations between AL and tumor characteristics (grade/histology).
    • To investigate the relationship between AL and survival outcomes.

    Main Methods:

    • Evaluated AL in 398 newly diagnosed endometrial cancer patients.
    • Calculated AL score based on 15 biologic variables (vital signs, anthropometrics, biomarkers, comorbidities).

    Related Experiment Videos

    Last Updated: Jun 23, 2026

    An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells
    09:48

    An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

    Published on: September 12, 2019

  • Used distribution-based thresholds to maintain heterogeneity in an obesity-dominant cohort.

    • Main Results:

    • High AL was observed in 68.7% of Black women versus 56.7% of White and Hispanic women.
    • Grade-dependent associations between AL and survival were found.
    • Black women with low-grade disease had shorter progression-free survival irrespective of AL.

    Conclusions:

    • AL scoring demonstrates heterogeneity in endometrial cancer, even with high obesity prevalence.
    • Differential associations of AL with survival by tumor grade and race suggest combined impacts of physiological burden and social/structural factors.
    • Findings underscore potential mechanisms driving endometrial cancer disparities.