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Related Concept Videos

Spermatogenesis01:41

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...
Nondisjunction01:21

Nondisjunction

Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold sister...

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Related Experiment Video

Updated: Jun 23, 2026

Preparation of Meiotic Chromosome Spreads from Zebrafish Spermatocytes
08:46

Preparation of Meiotic Chromosome Spreads from Zebrafish Spermatocytes

Published on: March 3, 2020

Clonal dynamics deviate from neutral drift in zebrafish spermatogenesis.

Jenna M Weber, Connor R Shrader, Drew B Shapiro

    Biorxiv : the Preprint Server for Biology
    |June 22, 2026
    PubMed
    Summary
    This summary is machine-generated.

    Spermatogonial stem cells (SSCs) change how they contribute to sperm over time. Their dynamics are not random, suggesting factors beyond chance influence male fertility and genetic inheritance.

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    Last Updated: Jun 23, 2026

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    Area of Science:

    • Reproductive Biology
    • Developmental Biology
    • Genetics

    Background:

    • Spermatogonial stem cells (SSCs) are crucial for maintaining male fertility throughout life.
    • The age-related changes in SSC clonal dynamics and their impact on sperm production are not well understood.

    Purpose of the Study:

    • To investigate the clonal dynamics of spermatogonial stem cells (SSCs) throughout the fertile lifespan in zebrafish.
    • To determine whether SSC clonal contributions to sperm production follow neutral or non-neutral dynamics over time.

    Main Methods:

    • Utilized in vivo CRISPR barcoding in zebrafish to label and track individual SSC clones.
    • Conducted monthly sampling of sperm to assess the contribution of labeled SSC clones over the lifespan.
    • Developed a mathematical model to quantify clonal drift rates and test neutrality hypotheses.

    Main Results:

    • Identified a subset of embryonic germ cells that contribute to adult sperm production.
    • Observed significant shifts in the relative contributions of individual SSC clones over time.
    • Found evidence of non-neutral clonal dynamics, including a positive correlation between clone size and drift rate, inconsistent with purely random drift.

    Conclusions:

    • SSC clonal dynamics are non-neutral throughout the zebrafish reproductive lifespan.
    • These non-neutral dynamics have significant implications for the transmission of genetic alleles.
    • The findings highlight the importance of considering factors beyond random chance in understanding male fertility and SSC behavior with age.