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Related Concept Videos

Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...

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Related Experiment Video

Updated: Jun 23, 2026

Quantitative Analysis of Alternative Pre-mRNA Splicing in Mouse Brain Sections Using RNA In Situ Hybridization Assay
11:22

Quantitative Analysis of Alternative Pre-mRNA Splicing in Mouse Brain Sections Using RNA In Situ Hybridization Assay

Published on: August 26, 2018

Systematic Profiling and Functional Characterization of Alternative Splicing in C. elegans Olfactory Learning.

Maoting Chen, Min Wu, Bina Koterniak

    Biorxiv : the Preprint Server for Biology
    |June 22, 2026
    PubMed
    Summary

    Alternative splicing (AS) regulates neuronal gene expression during learning. This process impacts learning-associated genes differently than transcript abundance, revealing a new layer of experience-based regulation.

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    Last Updated: Jun 23, 2026

    Quantitative Analysis of Alternative Pre-mRNA Splicing in Mouse Brain Sections Using RNA In Situ Hybridization Assay
    11:22

    Quantitative Analysis of Alternative Pre-mRNA Splicing in Mouse Brain Sections Using RNA In Situ Hybridization Assay

    Published on: August 26, 2018

    Detection of Alternative Splicing During Epithelial-Mesenchymal Transition
    11:48

    Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

    Published on: October 9, 2014

    A Molecular Readout of Long-term Olfactory Adaptation in C. elegans
    11:30

    A Molecular Readout of Long-term Olfactory Adaptation in C. elegans

    Published on: December 22, 2012

    Area of Science:

    • Neuroscience
    • Molecular Biology
    • Genetics

    Background:

    • Alternative splicing (AS) is a common mechanism in neuronal gene expression.
    • The role of AS in learning processes remains largely uncharacterized.

    Purpose of the Study:

    • To systematically investigate the function of AS in learning.
    • To profile translatome changes in C. elegans during a learning paradigm.

    Main Methods:

    • Profiling pan-neuronal translatome changes in C. elegans.
    • Analyzing genome-wide AS patterns in response to learning.
    • Investigating the role of the TWNK-1 gene and its isoforms in learning.

    Main Results:

    • AS remodels neuronal genes critical for learning at a genome-wide scale.
    • AS affects a distinct gene set compared to transcript abundance changes, acting as a separate regulatory layer.
    • The mitochondrial DNA helicase TWNK-1 exhibits learning-associated AS, with its isoforms regulating learning in sensory neurons.
    • AS of TWNK-1 modulates mitochondrial signaling to peripheral tissues, influencing physiological states essential for learning.

    Conclusions:

    • AS is a systematic regulator of learning in C. elegans.
    • AS shapes physiological states through mechanisms like mitochondrial signaling to facilitate learning.