Related Experiment Video
Updated: Jun 23, 2026

Preparation of Tunable Extracellular Matrix Microenvironments to Evaluate Schwann Cell Phenotype Specification
Published on: June 2, 2020
MIGRATION OF SCHWANN CELL PRECURSORS (SCPS) IS REGULATED BY INTERACTIONS OF N-CADHERIN-MEDIATED ADHESION AND
None:
Schwann cell precursors (SCPs) migrate with peripheral sensory axons from DRGs to target regions. SCP migration involves adhesions to substrata to stabilize advancing cell margins, and contractile forces that pull a SCP forward and break rear adhesions. Ncadherin on axons provides adhesion for SCPs, and ephrin-A2 signaling from axons stimulates SCP contractions to complete SCP translocation. Modulation of these adhesive and contractile forces regulates SCP migratioin during development of peripheral nerves.
Related Concept Videos
Cell Migration
Cell Migration
Cytoskeletal Coordination in Cell Migration
Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
Cell Motility through Blebbing
Blebbing Through the Matrix
In multicellular...
Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...

