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Related Experiment Video

Updated: Jun 23, 2026

Fabrication of the Composite Regenerative Peripheral Nerve Interface (C-RPNI) in the Adult Rat
10:35

Fabrication of the Composite Regenerative Peripheral Nerve Interface (C-RPNI) in the Adult Rat

Published on: February 25, 2020

A Fully Endovascular Neural Interface.

John Stanton, Giovanni Talei Franzesi, Eleonora Spinazzi

    Biorxiv : the Preprint Server for Biology
    |June 22, 2026
    PubMed
    Summary
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    Researchers developed a tiny, implantable device for endovascular neural stimulation. This ultrasound-powered neural interface can modulate autonomic functions, like blood pressure, offering a less invasive therapeutic approach.

    Area of Science:

    • Biomedical Engineering
    • Neuroscience
    • Medical Devices

    Background:

    • Electrical stimulation of neural circuits is a growing therapeutic strategy.
    • Endovascular devices offer a less invasive alternative to conventional implanted electrodes.
    • Existing techniques lack spatio-temporal specificity compared to invasive methods.

    Purpose of the Study:

    • To demonstrate a fully endovascular, wireless neural implant.
    • To utilize ultrasound for power and data transmission, independent of device orientation.
    • To establish a platform for neural interfaces enabling stimulation and recording.

    Main Methods:

    • Developed a sub-1-mm3 implant with piezoelectric transducers, capacitor, integrated circuit, and electrodes on a polyimide scaffold.

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    Surgical Implantation of Chronic Neural Electrodes for Recording Single Unit Activity and Electrocorticographic Signals
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    Surgical Implantation of Chronic Neural Electrodes for Recording Single Unit Activity and Electrocorticographic Signals

    Published on: February 24, 2012

    Related Experiment Videos

    Last Updated: Jun 23, 2026

    Fabrication of the Composite Regenerative Peripheral Nerve Interface (C-RPNI) in the Adult Rat
    10:35

    Fabrication of the Composite Regenerative Peripheral Nerve Interface (C-RPNI) in the Adult Rat

    Published on: February 25, 2020

    Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
    07:13

    Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

    Published on: October 20, 2021

    Surgical Implantation of Chronic Neural Electrodes for Recording Single Unit Activity and Electrocorticographic Signals
    08:26

    Surgical Implantation of Chronic Neural Electrodes for Recording Single Unit Activity and Electrocorticographic Signals

    Published on: February 24, 2012

  • Delivered the implant via microcatheter, analogous to neurovascular stents.
  • Demonstrated intravascular stimulation of the autonomic nervous system in rabbits via carotid artery access.

    • Main Results:

    • Achieved wireless power delivery and data telemetry using ultrasound, invariant to device orientation.
    • Successfully modulated blood pressure in rabbits through intravascular stimulation of the autonomic nervous system.
    • The implant self-expands to appose vessel walls upon deployment.

    Conclusions:

    • This endovascular implant represents a broadly applicable platform for neural interfaces.
    • The technology enables less invasive modulation of brain, autonomic, and immune functions.
    • Offers improved spatio-temporal specificity over noninvasive techniques.