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Updated: Jun 23, 2026

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
12:42

Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo

Published on: January 7, 2019

Emerging Oncolytic Viruses: Beyond Adenoviruses and Herpes Simplex Virus

Santosh Chokkakula1, Chengliang Yin2, Bing Yang3,4

  • 1Department of Microbiology, Chungbuk National University College of Medicine and Medical Research Institute, Cheongju, Chungbuk, 28644, South Korea.

Journal of Cancer
|June 22, 2026
PubMed

Insights

Oncolytic virotherapy uses viruses to kill cancer cells and activate the immune system. This innovative approach, with recent advances, offers a promising new strategy for cancer treatment.

Area of Science:

  • Oncology
  • Virology
  • Immunology

Background:

  • Oncolytic virotherapy is an emerging cancer treatment.
  • Oncolytic viruses (OVs) have a dual mechanism: direct tumor lysis and immune activation.
  • OVs can act as in situ vaccines, generating anti-tumor immune memory.

Purpose of the Study:

  • To review the mechanisms of oncolytic virotherapy.
  • To discuss clinical applications of OVs.
  • To highlight recent advancements in OV development.

Main Methods:

  • Review of scientific literature on oncolytic virotherapy.
  • Analysis of the mechanisms of action of OVs.
  • Examination of clinical trial data and regulatory approvals.

Main Results:

  • Oncolytic virotherapy offers direct tumor cell killing and stimulates a potent anti-tumor immune response.
  • Genetic engineering has improved OV specificity and efficacy, overcoming challenges like immune evasion.
  • The approval of talimogene laherparepvec (T-VEC) marks a significant milestone.

Conclusions:

  • Oncolytic virotherapy is a transformative strategy in cancer treatment.
  • Advances in genetic engineering are enhancing OV potential.
  • This approach holds promise for durable anti-tumor immunity.
Keywords:
cancer treatmentimmune responseimmunogenic cell death (ICD)metastatic melanomaoncolytic virotherapyoncolytic virusestalimogene laherparepvectumor cell lysis

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