Related Experiment Video

Updated: Jun 23, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Oxidized High-Density Lipoprotein and Cardiovascular Risk in Rheumatoid Arthritis

Linda Scharow1, Susann Patschan2, Nikolaos Pagonas1

  • 1Department of Cardiology und Rhythmology, University Clinic Ruppin-Brandenburg, Brandenburg Medical School (Theodor Fontane), Neuruppin, Brandenburg, Germany.

Journal of Clinical Medicine Research
|June 22, 2026
PubMed

Insights

Oxidized high-density lipoprotein (oxHDL) shows associations with cardiovascular risk indicators in rheumatoid arthritis (RA) patients. Further research is needed to confirm oxHDL

Area of Science:

  • Rheumatology
  • Cardiology
  • Biochemistry

Background:

  • Rheumatoid arthritis (RA) patients face significantly higher cardiovascular risk (CVR).
  • Current serological predictors for RA-associated CVR are lacking.
  • Elevated oxidized high-density lipoprotein (oxHDL) is linked to cardiovascular diseases.

Purpose of the Study:

  • To assess oxidized high-density lipoprotein (oxHDL) as a potential cardiovascular risk predictor in rheumatoid arthritis (RA).

Main Methods:

  • Observational cross-sectional study of 200 RA patients on disease-modifying anti-rheumatic drug (DMARD) therapy.
  • Collected anamnestic, clinical, and laboratory markers of cardiovascular morbidity and disease activity.
  • Quantified oxHDL using a fluorometric biochemical cell-free assay.

Main Results:

  • oxHDL levels correlated positively with body mass index (BMI) and number of tender small joints.
  • Higher oxHDL was observed in overweight and hypertensive RA patients.
  • oxHDL showed negative correlations with total cholesterol and prednisolone dose.

Conclusions:

  • oxHDL is associated with specific cardiovascular risk indicators in RA patients.
  • Prospective and follow-up studies are required to validate oxHDL's role in RA cardiovascular risk assessment.
Abstract

Keywords:
Cardiovascular riskDMARDsDisease activityRAoxHDL

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