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Updated: Jun 23, 2026
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
COVID-19 associated acute kidney injury
Praveen Kumar Chandra Sekar1, Ramakrishnan Veerabathiran1
1Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu 603103, India.
Infectious Diseases & Immunity
|June 22, 2026
Summary
Acute kidney injury (AKI) linked to Coronavirus Disease 2019 (COVID-19) presents diagnostic and treatment challenges. Understanding COVID-19 AKI
Area of Science:
- Nephrology
- Infectious Diseases
- Critical Care Medicine
Background:
- Coronavirus Disease 2019 (COVID-19) can lead to acute kidney injury (AKI), a serious complication.
- COVID-19 associated AKI (COVID-19 AKI) is linked to multisystem inflammation, increasing morbidity and mortality.
- Pathophysiological mechanisms include direct viral damage, cytokine release, and renin-angiotensin-aldosterone system disruption.
Purpose of the Study:
- To review the prevalence, pathophysiology, clinical presentation, and management of COVID-19 AKI.
- To highlight diagnostic approaches and treatment strategies for COVID-19 AKI.
- To identify areas for future research in COVID-19 AKI.
Main Methods:
- Literature review summarizing existing research on COVID-19 AKI.
- Analysis of diagnostic criteria and biomarkers for early detection.
- Evaluation of current management strategies and potential therapies.
Main Results:
- COVID-19 AKI presents with symptoms like reduced urine output and fluid retention.
- Biomarkers such as serum creatinine and blood urea nitrogen aid in early detection.
- Management involves avoiding nephrotoxic drugs; renal replacement therapy is an option for severe cases.
Conclusions:
- Further research is needed to fully understand COVID-19 AKI pathophysiology and optimize treatments.
- A multidisciplinary approach is crucial for comprehensive patient care.
- Targeted therapies and improved diagnostic criteria are essential for better patient outcomes.
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