Biological Applications of Functionalized Cerium Oxide Nanoparticles.

Area of Science:

• Nanotechnology
• Biomedical Engineering
• Materials Science

Background:

• Nanotechnology offers novel diagnostic and therapeutic solutions for diseases.
• Cerium oxide nanoparticles (CeO₂ NPs) possess unique properties like antioxidant and enzyme-mimicking activities, and good biocompatibility.
• These properties make CeO₂ NPs attractive for various biomedical applications.

Purpose of the Study:

• To review the latest research on functionalized CeO₂ NPs in biomedical applications.
• To explore the mechanisms of action and clinical potential of CeO₂ NPs.
• To address toxicity and safety concerns associated with CeO₂ NPs.

Main Methods:

• Literature review of recent studies on functionalized CeO₂ NPs.
• Analysis of research on CeO₂ NPs in anti-cancer, anti-infection, anti-inflammation, antioxidant, wound healing, and neuroprotection.
• Examination of imaging applications and safety profiles of CeO₂ NPs.

Main Results:

• Functionalized CeO₂ NPs demonstrate significant potential in anti-cancer, anti-infection, and anti-inflammatory activities.
• CeO₂ NPs exhibit notable antioxidant effects, aid in wound healing, and offer neuroprotection.
• Their enzyme-mimicking activity and biocompatibility support diverse therapeutic and diagnostic applications, including imaging.

Conclusions:

• Functionalized CeO₂ NPs represent a promising nanomaterial for various therapeutic and diagnostic applications.
• Further research into their mechanisms and clinical translation is warranted.
• Thorough evaluation of toxicity and safety is crucial for clinical implementation.