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Updated: Jun 23, 2026
07:48
An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 1, 2013
H3K18la-PSMG1 Axis in Bladder Cancer Progression: Curcumin as a Therapeutic Candidate.
Zhe Yu1, Jinge Zhang2, Zihuan Wang1
1Department of Urology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P. R. China.
International Journal of Biological Sciences
|June 22, 2026
Summary
Researchers identified PSMG1 as a key gene in muscle-invasive bladder cancer (MIBC) progression. Targeting PSMG1, potentially with Curcumin, may offer new therapeutic strategies for bladder cancer (BCa).
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Despite advances, muscle-invasive bladder cancer (MIBC) outcomes remain poor.
- Novel therapeutic targets are crucial for improving bladder cancer (BCa) management.
Purpose of the Study:
- To identify novel genes and develop a prognostic model for MIBC.
- To investigate the role of PSMG1 in BCa progression and explore potential therapeutic interventions.
Main Methods:
- Transcriptomic and proteomic analyses to identify MIBC-related genes (MIBC.RGs).
- Machine learning and single-cell transcriptomics for gene prioritization.
- In vitro and in vivo experiments to assess PSMG1 function.
- Epigenetic profiling and molecular docking studies.
Main Results:
- PSMG1 was identified as a key gene, significantly upregulated in BCa and progressively in MIBC.
- PSMG1 silencing inhibited BCa cell proliferation, invasion, and tumor growth.
- PSMG1 affects E-cadherin stability and EMT signaling.
- An H3K18la-PSMG1 regulatory axis was identified.
- Curcumin was prioritized as a potential PSMG1-targeting compound.
Conclusions:
- The H3K18la-PSMG1 axis is implicated in BCa progression.
- PSMG1 represents a potential therapeutic target for MIBC.
- Curcumin warrants further investigation for PSMG1-targeted BCa therapy.
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