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Operational Standard for Tissue-Extracted Collagen Facial Injection Techniques
Yinjie Ao1, Xiaoyang Wang2, Bing Shi3
1Department of Plastic Surgery and Medical Cosmetic Center, The Affiliated Eye Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Clinical, Cosmetic and Investigational Dermatology
|June 22, 2026
Summary
Tissue-extracted collagen injections offer facial rejuvenation but require standardized protocols. This standard improves safety and efficacy by outlining procedures, complication management, and combined treatments for better patient outcomes.
Area of Science:
- Dermatology
- Aesthetic Medicine
- Cosmetic Surgery
Background:
- Tissue-extracted collagen injections have been used for facial rejuvenation since 1981, particularly in the periorbital area.
- Differences in properties and metabolism compared to hyaluronic acid present application challenges and unique risks.
- Lack of unified international technical operating standards hinders consistent clinical practice.
Purpose of the Study:
- To establish a unified, standardized operational guideline for tissue-extracted collagen facial injections.
- To enhance the safety, efficacy, and clinical application of collagen-based facial rejuvenation techniques.
- To provide comprehensive guidance for medical professionals and institutions.
Main Methods:
- Synthesis of multicenter expert clinical experience.
- Systematic outlining of product characteristics, indications, contraindications, and precautions.
- Establishment of protocols for assessment, injection design, post-operative management, and complication handling.
- Development of multimodal treatment recommendations combining collagen with other aesthetic procedures.
Main Results:
- Standardized procedures and layered injection techniques improve safety and efficacy.
- Reduced incidence of complications like nodules and vascular embolism.
- Combined treatment strategies expand collagen's application and optimize recovery.
Conclusions:
- This operational standard provides systematic clinical guidance for tissue-extracted collagen facial injections.
- Promotes appropriate application and healthy development of collagen injection technology.
- Enhances overall treatment quality and patient satisfaction in facial rejuvenation.
