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Mesonephric-like adenocarcinoma of the uterine corpus: a case report
Ting Wang1, Wenlin Yang2, Xianglun Gong3
1Department of Pathology, Affiliated Hospital of Jining Medical University, Jining, China.
Abstract:
Mesonephric-like adenocarcinoma (MLA) is a rare and recently recognized subtype of endometrial and ovarian carcinoma characterized by distinctive morphology, immunophenotype, and aggressive clinical behavior. We report the case of a 60-year-old postmenopausal woman presenting with irregular vaginal bleeding. Imaging demonstrated a large uterine mass with deep myometrial invasion. Histopathological examination revealed diverse architectural patterns, including tubular, glandular, and slit-like structures, composed of cells with bland overlapping nuclei and occasional nuclear grooves. Immunohistochemical analysis showed positivity for GATA-3, TTF-1, EMA, and CK, and negativity for ER and PR, supporting the diagnosis of mesonephric-like adenocarcinoma of the uterine corpus.
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