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Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
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Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

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Uric Acid and Chronic Kidney Disease

Srinath Yadlapalli1, Divya K Nekkalapudi2, Jay B Wish1

  • 1Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN.

Kidney Medicine
|June 22, 2026
PubMed

Insights

Hyperuricemia is common in chronic kidney disease (CKD). Treating symptomatic hyperuricemia is recommended, but evidence for treating asymptomatic cases and its effect on CKD progression is mixed.

Area of Science:

  • Nephrology
  • Urology
  • Metabolic Diseases

Background:

  • Hyperuricemia is prevalent in chronic kidney disease (CKD) patients, worsening as kidney function declines.
  • The causal link between hyperuricemia and CKD progression is debated.
  • Treatment guidelines for symptomatic hyperuricemia in CKD are established, but evidence for treating asymptomatic hyperuricemia is inconsistent.

Purpose of the Study:

  • To review uric acid metabolism and its connection to CKD.
  • To evaluate the efficacy of uric acid-lowering agents in CKD patients.
  • To guide nephrologists in managing hyperuricemia, particularly asymptomatic cases, in CKD.

Main Methods:

  • Literature review of studies on uric acid metabolism in CKD.
  • Analysis of clinical trials investigating uric acid-lowering therapies.
  • Examination of current global society guidelines for hyperuricemia management.

Main Results:

  • The association between hyperuricemia and CKD is significant, but causality is uncertain.
  • Some studies suggest uric acid-lowering treatment may slow CKD progression, while others show no benefit.
  • Discrepancies exist among international guidelines regarding hyperuricemia treatment in CKD.

Conclusions:

  • Managing hyperuricemia in CKD requires careful consideration of symptomatic versus asymptomatic cases.
  • Choosing appropriate urate-lowering drugs and non-pharmacological therapies is crucial.
  • Minimizing medications that elevate uric acid levels is recommended for CKD patients.

Keywords:
Chronic kidney disease (CKD)hyperuricemiaurate-lowering drugsuric acidxanthine oxidase inhibitors

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