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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...

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Related Experiment Video

Updated: Jun 23, 2026

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
10:02

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Published on: October 3, 2020

Uric Acid and Chronic Kidney Disease.

Srinath Yadlapalli1, Divya K Nekkalapudi2, Jay B Wish1

  • 1Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN.

Kidney Medicine
|June 22, 2026
PubMed
Summary

Hyperuricemia is common in chronic kidney disease (CKD). Treating symptomatic hyperuricemia is recommended, but evidence for treating asymptomatic cases and its effect on CKD progression is mixed.

Keywords:
Chronic kidney disease (CKD)hyperuricemiaurate-lowering drugsuric acidxanthine oxidase inhibitors

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Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
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Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

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Last Updated: Jun 23, 2026

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
10:02

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Published on: October 3, 2020

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes
11:47

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

Area of Science:

  • Nephrology
  • Urology
  • Metabolic Diseases

Background:

  • Hyperuricemia is prevalent in chronic kidney disease (CKD) patients, worsening as kidney function declines.
  • The causal link between hyperuricemia and CKD progression is debated.
  • Treatment guidelines for symptomatic hyperuricemia in CKD are established, but evidence for treating asymptomatic hyperuricemia is inconsistent.

Purpose of the Study:

  • To review uric acid metabolism and its connection to CKD.
  • To evaluate the efficacy of uric acid-lowering agents in CKD patients.
  • To guide nephrologists in managing hyperuricemia, particularly asymptomatic cases, in CKD.

Main Methods:

  • Literature review of studies on uric acid metabolism in CKD.
  • Analysis of clinical trials investigating uric acid-lowering therapies.
  • Examination of current global society guidelines for hyperuricemia management.

Main Results:

  • The association between hyperuricemia and CKD is significant, but causality is uncertain.
  • Some studies suggest uric acid-lowering treatment may slow CKD progression, while others show no benefit.
  • Discrepancies exist among international guidelines regarding hyperuricemia treatment in CKD.

Conclusions:

  • Managing hyperuricemia in CKD requires careful consideration of symptomatic versus asymptomatic cases.
  • Choosing appropriate urate-lowering drugs and non-pharmacological therapies is crucial.
  • Minimizing medications that elevate uric acid levels is recommended for CKD patients.