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Bilateral panuveitis associated with letrozole therapy.

Brian T Cheng1, Justin C Muste1,2, Sidra Zafar1,2

  • 1Wills Eye Hospital, Philadelphia, Pennsylvania USA.

Retinal Cases & Brief Reports
|June 22, 2026
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Summary

This study details a rare case of bilateral panuveitis, a severe eye inflammation, linked to letrozole treatment for breast cancer. Promptly stopping letrozole and using corticosteroids led to vision recovery.

Keywords:
drug reactionletrozoleocular inflammationpanuveitis

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Area of Science:

  • Ophthalmology
  • Oncology
  • Pharmacology

Background:

  • Letrozole is a standard treatment for estrogen receptor-positive breast cancer.
  • Aromatase inhibitors like letrozole can have ocular side effects.
  • Panuveitis is a serious intraocular inflammation.

Purpose of the Study:

  • To report a novel case of bilateral panuveitis.
  • To describe the association between letrozole therapy and panuveitis.
  • To emphasize early recognition and management of drug-induced uveitis.

Main Methods:

  • Retrospective chart review of a single patient case.
  • Clinical presentation and treatment course documentation.
  • Exclusion of infectious and systemic inflammatory causes.

Main Results:

  • A 39-year-old female developed bilateral panuveitis six weeks after starting letrozole.
  • Symptoms included anterior chamber inflammation, vitreous inflammation, perivenular sheathing, retinal hemorrhages, and retinal whitening.
  • Cessation of letrozole and corticosteroid treatment resulted in complete resolution of inflammation and improved visual acuity.

Conclusions:

  • Letrozole-induced panuveitis is a previously unreported adverse effect.
  • Detailed medication history is crucial for diagnosing drug-induced uveitis.
  • Interdisciplinary collaboration and timely intervention are key for favorable visual outcomes in drug-induced uveitis.