Related Experiment Videos

Impact of comorbid mental disorders on in‑hospital mortality and complications after ST‑segment elevation myocardial

Akash Gopal1, Prit Patel1, Abdul Rasheed Bahar2

  • 1Wayne State University School of Medicine, Detroit, MI, USA.

Future Cardiology
|June 22, 2026
PubMed

Insights

Female patients with ST-segment elevation myocardial infarction (STEMI) and psychiatric comorbidities face higher in-hospital mortality. This study highlights sex-based outcome differences in STEMI patients with mental health conditions.

Area of Science:

  • Cardiology
  • Psychiatry
  • Health Outcomes Research

Background:

  • Psychiatric comorbidities are prevalent in ST-segment elevation myocardial infarction (STEMI) patients.
  • These comorbidities may influence in-hospital outcomes, with potential sex-based disparities.

Purpose of the Study:

  • To investigate the association between female sex and in-hospital outcomes among STEMI patients with psychiatric comorbidities.
  • To compare outcomes between males and females and conduct subgroup analyses for specific psychiatric conditions.

Main Methods:

  • Retrospective cross-sectional observational study using the National Inpatient Sample.
  • Analysis of adults hospitalized with STEMI and psychiatric comorbidities.
  • Multivariable logistic regression and propensity-score matching were employed.

Main Results:

  • Female sex was linked to increased in-hospital mortality (aOR 1.13) and pulmonary embolism (aOR 1.54).
  • Females had lower odds of cardiogenic shock (aOR 0.85), acute heart failure, and arrhythmias.
  • Post-traumatic stress disorder in females correlated with higher mortality (aOR 2.40).

Conclusions:

  • Female sex is associated with higher in-hospital mortality and fewer adverse complications in STEMI patients with psychiatric disorders.
  • Findings underscore the heterogeneity of psychiatric comorbidities and varying outcomes based on sex and specific conditions.
Abstract

Keywords:
Acute coronary syndromeNational Impatient Sample (NIS)in-hospital mortalitymental healthsex-based disparities

Related Concept Videos

Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...