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Physical Organic Studies on the Stereoionic Interactions in Asymmetric Primary Aminocatalysis

Yuchen Zhang1, Long Zhang1, Qifeng Lin1

  • 1Center of Basic Molecular Science, Department of Chemistry, Tsinghua University, Beijing 100084, China.

Accounts of Chemical Research
|June 22, 2026
PubMed
Summary

Chiral primary vicinal diamines act as enzyme mimics, utilizing unique noncovalent interactions beyond hydrogen bonding for asymmetric catalysis. These interactions, including proton-shuttle networks and steric effects, enable precise control in carbonyl transformations.

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