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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Murine Superficial Lymph Node Surgery
04:36

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Published on: May 21, 2012

UBE2F impedes CD8 T cell memory.

Li Zhong1,2, Hua Gu1,2,3

  • 1Montreal Clinical Research Institute , Montreal, Canada.

The Journal of Experimental Medicine
|June 22, 2026
PubMed
Summary
This summary is machine-generated.

The E2 ubiquitin-conjugating enzyme UBE2F limits the development of long-term CD8 T cell memory, which is essential for controlling viral infections and cancer.

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A DNA/Ki67-Based Flow Cytometry Assay for Cell Cycle Analysis of Antigen-Specific CD8 T Cells in Vaccinated Mice

Published on: January 5, 2021

Area of Science:

  • Immunology
  • Molecular Biology
  • Cellular Biology

Background:

  • Long-term immune memory is crucial for combating persistent viral infections and cancer.
  • CD8 T cells are key players in adaptive immunity and immunological memory.

Purpose of the Study:

  • To investigate the role of the E2 ubiquitin-conjugating enzyme UBE2F in regulating CD8 T cell memory.
  • To understand the molecular mechanisms by which UBE2F influences immune memory maintenance.

Main Methods:

  • Utilized mouse models and in vitro assays to study CD8 T cell responses.
  • Investigated the enzymatic activity and cellular localization of UBE2F.
  • Assessed the impact of UBE2F modulation on T cell memory formation and recall responses.

Main Results:

  • UBE2F was identified as a negative regulator of long-term CD8 T cell memory.
  • Depletion of UBE2F enhanced the persistence and functionality of memory CD8 T cells.
  • UBE2F activity was found to directly impact T cell differentiation and survival pathways.

Conclusions:

  • UBE2F acts as a brake on the establishment of robust and durable CD8 T cell memory.
  • Targeting UBE2F may offer a novel therapeutic strategy to improve T cell-based immunotherapies for cancer and chronic infections.