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Updated: Jun 23, 2026

An Allelotyping PCR for Identifying Salmonella enterica serovars Enteritidis, Hadar, Heidelberg, and Typhimurium
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An Allelotyping PCR for Identifying Salmonella enterica serovars Enteritidis, Hadar, Heidelberg, and Typhimurium

Published on: July 22, 2011

Clinical and Antimicrobial Resistance Patterns of Salmonella enterica Serovar Paratyphi A Infections in Pediatric

Surendra Bahadur Mathur1, Dharmendra Kumar Singh2, Naz Perween3

  • 1Department of Pediatrics, Postgraduate Institute of Child Health, Sector - 30, Gautam Buddha Nagar, Noida, Uttar Pradesh, India. sbmathur05@gmail.com.

Indian Pediatrics
|June 22, 2026
PubMed

Insights

Pediatric Salmonella Paratyphi A infections show emerging resistance to common antibiotics like ceftriaxone. However, children responded well to tailored antimicrobial therapy, indicating favorable short-term outcomes despite resistance patterns.

Area of Science:

  • Pediatric Infectious Diseases
  • Antimicrobial Resistance
  • Bacteriology

Background:

  • Salmonella enterica serovar Paratyphi A (SPA) infections pose a significant public health concern in children.
  • Understanding the clinical and microbiological characteristics of SPA is crucial for effective management.

Purpose of the Study:

  • To analyze the clinical profiles of pediatric SPA infections.
  • To determine antibiotic susceptibility patterns and biochemical characteristics of SPA isolates in children.

Main Methods:

  • Retrospective observational study of hospitalized pediatric patients (<18 years) with blood culture-confirmed SPA infection.
  • Data collection included demographics, clinical features, treatment, antibiotic susceptibility, and outcomes.
  • Statistical analysis performed using SPSS (P<0.05 significance).

Main Results:

  • Forty-five pediatric cases analyzed; mean age 7 years.
  • Fever, vomiting, and abdominal pain were common clinical signs.
  • Significant resistance observed to ceftriaxone (31%) and fluoroquinolones (85-100%).
  • High susceptibility noted for trimethoprim+sulfamethoxazole (100%) and chloramphenicol (90.6%).
  • Extended-spectrum beta-lactamase (ESBL) and AmpC beta-lactamase production detected in 35.6% and 26.7% of isolates, respectively.

Conclusions:

  • Emerging antimicrobial resistance in pediatric SPA isolates is a growing concern.
  • Short-term clinical outcomes were favorable with appropriate antimicrobial therapy.
  • Tailored treatment strategies are essential for managing pediatric SPA infections effectively.
Abstract

Keywords:
Antibiotic resistanceAntimicrobial stewardshipBeta-lactamCephalosporinEnteric feverMultidrug-resistant bacteria

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