Multi-Omics Pan-Cancer Bioinformatics Workflow for Evaluating PTDSS1 and PTDSS2 as Prognostic and Immune Biomarkers

Area of Science:

• Molecular Biology
• Oncology
• Immunology

Background:

• Phosphatidylserine synthesis enzymes (PTDSS1 and PTDSS2) are crucial for cellular functions.
• Their abnormal expression is linked to breast cancer progression and poor outcomes.
• Comprehensive roles across diverse cancer types are not well understood.

Purpose of the Study:

• To conduct a pan-cancer analysis of PTDSS1 and PTDSS2.
• Evaluate their diagnostic, prognostic, immune infiltration, and immunotherapeutic relevance.
• Investigate their association with clinical stage and tumor stemness.

Main Methods:

• Utilized multiple public databases for comprehensive analysis.
• Analyzed gene expression, clinical correlations, and survival outcomes.
• Assessed tumor stemness scores and immune-related characteristics.

Main Results:

• PTDSS1 and PTDSS2 are widely expressed and significantly upregulated in most tumor tissues.
• High expression correlates with poorer overall survival (OS) in several cancers.
• Associated with clinical stage, tumor stemness, tumorigenesis, immune regulation, and chemoresistance.

Conclusions:

• PTDSS1 and PTDSS2 possess significant prognostic value across multiple cancer types.
• They may serve as potential biomarkers for cancer diagnosis and prognosis.
• These enzymes represent promising targets for novel cancer immunotherapies.