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Updated: Jun 24, 2026

Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation

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Published on: October 29, 2013

Membrane-Coated Microsphere Functionalization with Polypeptides.

Christopher J Randolph¹, Sneha Bhat¹, Eva de Alba¹

¹Department of Bioengineering, School of Engineering, University of California, Merced 5200 Lake Road, Merced, California 95343, United States.

Biomacromolecules

|June 22, 2026

Summary

This summary is machine-generated.

Researchers developed a novel method to create synthetic membrane-coated microspheres. These functionalized microspheres enable the study of membrane-dependent protein functions for advanced biotechnological applications.

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Published on: August 15, 2016

Area of Science:

Biotechnology and biomaterials science
Biophysics and molecular biology

Background:

Microspheres are crucial for biotechnological applications, often functionalized with proteins and peptides.
Many protein functions are influenced by lipid membranes, yet membrane-coated microspheres are scarce.
Existing methods lack efficient ways to integrate membrane-mimicking functionalities.

Purpose of the Study:

To develop a simple and versatile method for creating synthetic membrane-coated microspheres.
To enable the functionalization of these microspheres with peptides and proteins for bioconjugation.
To facilitate studies on protein functions that are enhanced by lipid bilayers.

Main Methods:

Fabrication of microspheres with integrated synthetic membranes.
Functionalization with peptides for bioconjugation and proteins (e.g., DNA-binding protein).
Characterization using confocal fluorescence microscopy, optical traps, and flow cytometry.

Main Results:

Successful production of membrane-coated microspheres with diverse materials and sizes.
Demonstration of functionalized peptide and protein activity on microspheres.
Quantification of protein-DNA binding forces and near 100% labeling efficiency via flow cytometry.

Conclusions:

A novel, versatile method for creating multifunctional membrane-coated microspheres has been established.
These microspheres are suitable for studying protein functions influenced by lipid bilayers.
Opens avenues for advanced biotechnological tools and biophysical studies.