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Updated: Jun 24, 2026

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
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Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Published on: November 8, 2024

Automated Operant Intermittent Alcohol Drinking In Socially-Housed Mice via The Intellicage Testing System.

Lucy G Anderson1, Roland Bock1, Theodore H Averbeck1

  • 1Section on Neurobiology of Compulsive Behaviors, National Institute on Mental Health, Intramural Research Program, National Institutes of Health.

Journal of Visualized Experiments : Jove
|June 22, 2026
PubMed
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This study introduces a novel social alcohol drinking task for mice, reducing stress from social isolation. The automated IntelliCage system allows high-throughput assessment of alcohol preference in preclinical models of alcohol use disorder (AUD).

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Pharmacology

Background:

  • Social isolation in rodents confounds behavioral studies, yet is common in alcohol preference testing.
  • Preclinical models of alcohol use disorder (AUD) often use singly housed mice, introducing stress.
  • There is a need for ethologically relevant, high-throughput methods to study alcohol drinking behaviors.

Purpose of the Study:

  • To describe a social alcohol drinking task for mice using the IntelliCage system.
  • To enable high-throughput, automated assessment of alcohol drinking behaviors without social isolation stress.
  • To provide open-source methods for analyzing operant alcohol drinking data relevant to AUD.

Main Methods:

  • Utilized the IntelliCage testing system for simultaneous assessment of operant alcohol drinking in up to 16 same-sex mice.

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Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
07:31

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

Related Experiment Videos

Last Updated: Jun 24, 2026

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
08:45

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Published on: November 8, 2024

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
07:31

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice

Published on: January 7, 2019

  • Employed radiofrequency identification (RFID) transponders for unique mouse identification.
  • Implemented a chronic, intermittent 20% alcohol access paradigm over six weeks, with software-controlled access and optional quinine adulteration.

    • Main Results:

    • The system automatically recorded visits, nosepokes, and lick data for each mouse.
    • The protocol allows for voluntary, operant alcohol self-administration.
    • Data analysis using provided open-source code enables efficient and ethologically relevant assessment of alcohol drinking.

    Conclusions:

    • The described social alcohol drinking task offers a high-throughput, automated, and ethologically relevant method for preclinical AUD research.
    • This approach mitigates confounding effects of social isolation stress in mouse models.
    • The availability of detailed methods and open-source code facilitates broader adoption and advancement in AUD research.