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Related Experiment Video

Updated: Jun 24, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Challenges and Future Trends in Large Vessel Vasculitis.

Maria Sandovici1, Kornelis S M van der Geest1, Rosanne D Reitsema2

  • 1Department of Rheumatology and Clinical Immunology (M.S., K.S.M.v.d.G., E.B.), University of Groningen, University Medical Centre Groningen, The Netherlands.

Circulation
|June 22, 2026
PubMed
Summary

Large vessel vasculitis (LVV) diagnosis is challenging due to varied symptoms. Advances in vascular imaging and targeted therapies offer improved patient outcomes and management strategies for conditions like giant cell arteritis and Takayasu arteritis.

Keywords:
Takayasu arteritisdiagnosticsgiant cell arteritislarge vessel vasculitismanagementpathogenesis

Related Experiment Videos

Last Updated: Jun 24, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Area of Science:

  • Rheumatology
  • Immunology
  • Cardiovascular Medicine

Background:

  • Large vessel vasculitis (LVV) encompasses giant cell arteritis and Takayasu arteritis, primarily affecting women with distinct geographic prevalence.
  • Pathogenesis involves genetic, environmental, immune, and aging factors, complicating diagnosis due to nonspecific symptoms.

Purpose of the Study:

  • To provide an in-depth update on current challenges and future trends in large vessel vasculitis (LVV).
  • To enhance understanding of LVV pathogenesis, diagnostic features, and management strategies.

Main Methods:

  • This narrative review synthesizes current literature on LVV.
  • Focuses on diagnostic challenges, novel imaging techniques, and emerging targeted therapies.

Main Results:

  • Clinical diagnosis of LVV is often difficult due to nonspecific symptoms.
  • Advanced vascular imaging and molecular imaging show promise for diagnosis and monitoring.
  • New targeted therapies aim to improve outcomes and reduce glucocorticoid side effects.

Conclusions:

  • Ongoing research is crucial for understanding LVV mechanisms and developing targeted therapies.
  • Improved patient assessment and lifelong management strategies are needed.
  • Addressing cardiovascular complications related to LVV and its treatment is essential.