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Updated: Jun 24, 2026

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
Published on: June 9, 2018
Pre-Amyloidosis Red-Flag Clinical Diagnoses in Light Chain (AL) Versus Age-Related Transthyretin (ATTRwt)
Noel Estrada-Merly1, Liliana E Pezzin2, Rodney Sparapani3
1Department of Medicine, Division of Hematology/Oncology, Medical College of Wisconsin, 9200 W Wisconsin Ave, Office #C4204, Milwaukee, WI, 53226, United States, 1 414 805 0637.
Unlabelled:
This electronic health record-based study highlights distinct diagnostic patterns preceding a diagnosis of light chain (AL) and wild-type transthyretin (ATTRwt) amyloidosis; AL amyloidosis was more frequently preceded by renal, gastrointestinal, neurologic, and clonal plasma cell disorders, whereas ATTRwt amyloidosis was more commonly associated with cardiac manifestations and carpal tunnel syndrome.
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