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Related Experiment Video

Updated: Jun 24, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Light-Activated Ruthenium Nanoclusters Reprogram the Metabolic-Quorum Sensing Axis for Precision Periodontitis

Jing Zhou¹, Xiaolin Sun¹, Chengyu Liu²

¹Department of Oral Implantology, Hospital of Stomatology, Jilin Provincial Key Laboratory of Sciences and Technology for Stomatology Nanoengineering, Jilin University, Changchun, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

|June 22, 2026

Summary

This summary is machine-generated.

Targeting Veillonella parvula

Keywords:

antibacterial therapy bacterial metabolism nanoclusters periodontitis photoelectrochemical catalysis quorum sensing ruthenium

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Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

Area of Science:

Microbiome Research
Nanotechnology Applications
Periodontal Disease Therapeutics

Background:

Periodontitis is a polymicrobial disease fueled by bacterial metabolic interactions.
Commensal bacteria like Veillonella parvula support the virulence of keystone pathogens such as Porphyromonas gingivalis.
Targeting these interdependencies offers a novel therapeutic approach for periodontitis.

Purpose of the Study:

To investigate the potential of disrupting Veillonella parvula's nitrate metabolism to control Porphyromonas gingivalis virulence.
To develop and evaluate engineered L-cysteine-capped ruthenium nanoclusters (Ru NCs) for targeted nitrate reduction.
To assess the therapeutic efficacy of light-activated Ru NCs in a rat periodontitis model.

Main Methods:

Engineering L-cysteine-capped ruthenium nanoclusters (Ru NCs) for photocatalytic nitrate reduction.
Utilizing 660 nm light to activate Ru NCs for nitrate-to-ammonium conversion.
Employing multiomics analyses to assess metabolic changes in V. parvula and P. gingivalis.
Evaluating the effects of Ru NCs on biofilm formation, P. gingivalis virulence genes, and alveolar bone loss in a rat model.

Main Results:

Ru NCs efficiently reduced nitrate, depleting the nutrient pool for V. parvula and disrupting support for P. gingivalis.
Photocatalytic treatment significantly reduced biofilm biomass, P. gingivalis activity, and key virulence gene expression.
Multiomics data confirmed nitrate-dependent metabolic collapse in V. parvula and impaired metabolism in P. gingivalis.
In vivo, light-activated Ru NCs attenuated bone loss, preserved collagen, and modulated the local cytokine profile.

Conclusions:

Targeting interspecies metabolic dependencies, specifically V. parvula nitrate metabolism, is a viable strategy against periodontitis.
Engineered Ru NCs offer a novel photocatalytic approach to disrupt microbial fuel chains.
This microbiome-targeted therapy presents a new paradigm for managing periodontal disease progression.