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Yorkie/Scalloped-OVOL-Rac1 axis controls insect wing development by promoting cell proliferation.

Jing Zhang1, Yanan Zhang2, Babar Hussain Chang3

  • 1Shanxi Key Laboratory of Nucleic Acid Biopesticides, Institute of Applied Biology, Shanxi University, Taiyuan, Shanxi 030006, China; College of Life Science, Shanxi University, Taiyuan, Shanxi 030006, China.

Journal of Genetics and Genomics = Yi Chuan Xue Bao
|June 22, 2026
PubMed
Summary

The Yorkie/Scalloped-OVOL-Rac1 pathway is crucial for insect wing development. This pathway regulates cell proliferation and organ size by controlling gene expression during development.

Keywords:
Cell proliferationHippo signalingOVO-likeRac1Wing development

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Area of Science:

  • Developmental biology
  • Genetics
  • Molecular biology

Background:

  • Organ size regulation is key in developmental biology.
  • The Hippo signaling pathway is conserved and controls tissue growth.
  • Its role in insect wing development is not fully understood.

Purpose of the Study:

  • Identify key regulators of Hippo signaling in insect wing development.
  • Elucidate the genetic mechanisms of wing morphogenesis.
  • Understand how organ size is controlled.

Main Methods:

  • Investigated the role of OVOL in Locusta migratoria and Drosophila melanogaster.
  • Utilized transcriptomic analysis to identify downstream effectors.
  • Performed functional validation of identified genes and pathways.

Main Results:

  • OVOL is essential for normal wing formation, regulating cell proliferation and trichome patterning.
  • Rac1 is a downstream effector of OVOL, promoting proliferative growth.
  • The Yorkie/Scalloped (Yki/Sd) complex directly activates OVOL expression via a GATAA motif.

Conclusions:

  • Established the Yorkie/Sd-OVOL-Rac1 pathway governing insect wing development.
  • Demonstrated OVOL's critical role as a mediator of Hippo signaling.
  • Provided mechanistic insights into organ size regulation.