Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Three-dimensional sonographic diagnosis of diamniotic conjoined twins.

Quantitative imaging in medicine and surgery·2026
Same author

Single-cell Transcriptome Profiling Reveals Gene Regulatory Networks and Key Genes in the Root Epidermis and Cortical Cells Associated with Early Nodulation in Glycine Max.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Linking childhood adversity and daily hassles to adolescent sleep behaviors: Diurnal cortisol as a mediating pathway.

Developmental psychology·2026
Same author

Bank Resolution Trade-Offs Under Coupled Liquidity and Credit Risks: An Agent-Based Network Analysis of Systemic Stability.

Entropy (Basel, Switzerland)·2026
Same author

Immune-related nephritis, ureteritis and cystitis secondary to immune checkpoint inhibitors: A case report and review of the literature.

Experimental and therapeutic medicine·2026
Same author

A Multi-omics Framework Combining Genomics and Proteomics for Silicosis Prediction in Chinese Workers - Jiangsu Province, China, 2023-2024.

China CDC weekly·2026

Related Experiment Video

Updated: Jun 24, 2026

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

Selenium nanoparticles alleviate ulcerative colitis by regulating macrophage mitochondrial dynamics.

Jiajing Chang1, Xiaonan Zeng1, Runan Zhang1

  • 1School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi, 710072, China.

Free Radical Biology & Medicine
|June 22, 2026
PubMed
Summary

Biogenic selenium nanoparticles (SeNPs) alleviate ulcerative colitis by restoring macrophage function and mitochondrial health. This study highlights SeNPs as a promising nanotherapy for gut inflammation and barrier repair.

Keywords:
ER-mitochondria communicationMacrophage polarizationMitochondrial dynamicsNLRP3 inflammasomeSelenium nanoparticlesUlcerative colitis

More Related Videos

Establishment of Coloproctitis Cancer Model in Mice and Evaluation of Therapeutic Effect of Chinese Medicine
06:24

Establishment of Coloproctitis Cancer Model in Mice and Evaluation of Therapeutic Effect of Chinese Medicine

Published on: October 13, 2023

Related Experiment Videos

Last Updated: Jun 24, 2026

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

Establishment of Coloproctitis Cancer Model in Mice and Evaluation of Therapeutic Effect of Chinese Medicine
06:24

Establishment of Coloproctitis Cancer Model in Mice and Evaluation of Therapeutic Effect of Chinese Medicine

Published on: October 13, 2023

Area of Science:

  • Immunology and Nanomedicine
  • Gastroenterology and Molecular Biology

Background:

  • Ulcerative colitis (UC) progression involves macrophage dysfunction and mitochondrial damage.
  • Selenium homeostasis is crucial for maintaining intestinal mucosal immunity and barrier integrity.

Purpose of the Study:

  • To investigate the protective effects of biogenic selenium nanoparticles (SeNPs) against experimental colitis.
  • To elucidate the underlying mechanisms involving macrophage polarization and mitochondrial dynamics.

Main Methods:

  • Utilized dextran sulfate sodium (DSS)-induced colitis mouse model and lipopolysaccharide (LPS)-activated THP-1 macrophages.
  • Employed transcriptomic and molecular analyses to assess macrophage polarization, mitochondrial function, and signaling pathways.
  • Investigated the role of selenium deficiency and SeNPs in intestinal barrier integrity and epithelial regeneration.

Main Results:

  • Selenium deficiency exacerbated DSS-induced colitis; biogenic SeNPs showed superior efficacy over inorganic selenium.
  • SeNPs promoted a shift from pro-inflammatory M1 to restorative macrophage profiles, preserving intestinal barrier integrity.
  • SeNPs restored endoplasmic reticulum (ER)-resident selenoprotein expression, modulated mitochondria-associated membrane (MAM) signaling, and rebalanced mitochondrial dynamics, reducing reactive oxygen species (ROS) and NLRP3 inflammasome activation.

Conclusions:

  • Biogenic SeNPs effectively alleviate experimental colitis by restoring macrophage mitochondrial dynamics and enhancing immune-epithelial crosstalk.
  • SeNPs represent a potential nanotherapeutic strategy for UC by improving intestinal homeostasis and barrier function.
  • The study underscores the importance of selenium in mucosal immunity and highlights SeNPs' therapeutic potential.