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Updated: Jun 24, 2026

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
Published on: December 16, 2021
Adaptive immune responses against Lachnospiraceae-derived flagellins and their role in inflammatory bowel disease
Daniëlle M H Barendregt1, Qing Zhao2, Janneke N Samsom1
1Laboratory of Pediatrics, division Gastroenterology and Nutrition, Erasmus University Medical Center, Rotterdam, the Netherlands.
Abstract:
Adaptive immune responses, including B and T cell responses, play important roles in establishing and maintaining the mutualistic relationship between the host and intestinal microbiota. Host-microbiota mutualism is disrupted in various immune-mediated inflammatory diseases, including Crohn's disease (CD). Aberrant inflammatory memory CD4+ T cell responses contribute to disease chronicity in CD. One of the few identified microbial targets of the CD-associated immune response that has been extensively studied is Lachnospiraceae-derived flagellin protein. In this review, we provide an overview of current knowledge on innate, B, and T cell responses against Lachnospiraceae-derived flagellins in health and disease. We discuss the circumstances and immunological mechanisms that underlie these responses, as well as their clinical significance and potential as therapeutic targets.
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