Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

International Xenotransplantation Association (IXA) Position Paper on Kidney Xenotransplantation.

Transplantation·2025
Same author

International Xenotransplantation Association (IXA) Position Paper on Kidney Xenotransplantation.

Xenotransplantation·2025
Same author

International Xenotransplantation Association (IXA) Position Paper on the History, Current Status, and Regulation of Xenotransplantation.

Xenotransplantation·2025
Same author

Xenotransplantation of a Porcine Kidney for End-Stage Kidney Disease.

The New England journal of medicine·2025
Same author

Surveillance and prevention of infection in clinical xenotransplantation.

Clinical microbiology reviews·2025
Same author

Modulation of Monocyte Effector Functions and Gene Expression by Human Cytomegalovirus Infection.

Viruses·2025
Same journal

Pharyngeal gonorrhea in Ugandan men with urogenital gonorrhea: differences in antimicrobial resistance and strain types between anatomical sites.

The Journal of infectious diseases·2026
Same journal

Proactive Surveillance of Public Swimming Pools to Prevent Delayed Detection of Cryptosporidiosis Outbreaks.

The Journal of infectious diseases·2026
Same journal

Diverse genetic lineages spreading across healthcare and community boundaries underlie extended-spectrum cephalosporin-resistant Enterobacterales (ESCrE) colonization burden in Botswana.

The Journal of infectious diseases·2026
Same journal

Retraction of: Tracking Plasmodium knowlesi Through Fecal DNA for Monitoring Zoonotic Transmission in Wild Macaques Across Southeast and South Asia.

The Journal of infectious diseases·2026
Same journal

Can malaria induce loss of vaccine immunity.

The Journal of infectious diseases·2026
Same journal

NET-inducing ability of Cutibacterium acnes clinical isolates is associated with pathogenicity in acne vulgaris.

The Journal of infectious diseases·2026
See all related articles

Related Experiment Video

Updated: Jun 24, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Allelic Variations in Genes Modulating Immune Function: Impact on Infections in Organ Transplantation.

Alejandro De La Hoz1, Jay A Fishman1

  • 1Division of Infectious Diseases and Transplantation Center, Mass General Brigham and Harvard Medical School, Boston, Massachusetts, USA.

The Journal of Infectious Diseases
|June 22, 2026
PubMed
Summary
This summary is machine-generated.

Genetic variations influence infection risk in solid organ transplant recipients. Identifying high-risk genotypes can personalize infection prevention strategies for better patient outcomes.

Keywords:
Allelic VariationGenetic sequencingImmunosuppressionInfectionSingle nucleotide polymorphismTransplantationimmune pathwaysimmunocompromised hostinnate and adaptive immune functionorgan transplantation

More Related Videos

Differentiating Functional Roles of Gene Expression from Immune and Non-immune Cells in Mouse Colitis by Bone Marrow Transplantation
14:43

Differentiating Functional Roles of Gene Expression from Immune and Non-immune Cells in Mouse Colitis by Bone Marrow Transplantation

Published on: October 1, 2012

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Related Experiment Videos

Last Updated: Jun 24, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
18:48

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

Published on: August 12, 2017

Differentiating Functional Roles of Gene Expression from Immune and Non-immune Cells in Mouse Colitis by Bone Marrow Transplantation
14:43

Differentiating Functional Roles of Gene Expression from Immune and Non-immune Cells in Mouse Colitis by Bone Marrow Transplantation

Published on: October 1, 2012

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
11:49

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Area of Science:

  • Transplantation immunology
  • Infectious disease epidemiology
  • Human genetics

Background:

  • Solid organ transplantation (SOT) recipients face variable infection risks due to complex interactions.
  • Immunosuppressive regimens alone do not fully explain differences in susceptibility to viral, bacterial, and fungal infections.
  • Host immune function, influenced by genetics, plays a critical role in infection risk.

Purpose of the Study:

  • To explore the role of allelic variation in genes of innate immunity on infectious risk post-SOT.
  • To understand how genetic polymorphisms contribute to the variability in infection susceptibility among transplant recipients.

Main Methods:

  • Review of accumulating evidence on genetic variations (e.g., single nucleotide polymorphisms) in innate immune genes.
  • Analysis of associations between specific genetic variants and susceptibility to various infections (bacterial, fungal, viral).

Main Results:

  • Allelic variations in genes encoding pattern recognition receptors, complement components, phagocyte and NK cell functions, opsonins, and cytokines are linked to altered infection risk.
  • Specific genetic variants are associated with increased susceptibility to cytomegalovirus, Epstein-Barr virus, BK polyomavirus, and hepatitis viruses.
  • These genetic factors contribute to differential risk for bacterial and invasive fungal infections.

Conclusions:

  • Host genetic makeup significantly impacts susceptibility to infections following SOT.
  • Identification of high-risk genotypes can pave the way for precision transplantation.
  • Future strategies may include individualized surveillance, prophylaxis, and host-directed therapies based on genetic profiles.