Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular tachycardia.
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...
Mitral Valve Prolapse III: Nursing Management01:19

Mitral Valve Prolapse III: Nursing Management

The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...
Mitral Regurgitation IV: Nursing Management01:28

Mitral Regurgitation IV: Nursing Management

Mitral regurgitation (MR) is a condition where the mitral valve does not close properly, leading to the backward flow of blood from the left ventricle into the left atrium during systole. This condition can arise from various causes, including rheumatic fever, infective endocarditis, or degenerative valve disease. Effective nursing management is crucial to optimizing patient outcomes and involves comprehensive assessment and targeted interventions.Comprehensive Patient AssessmentA detailed...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

UNICORN During Transcatheter Aortic Valve Replacement in Native and Bioprosthetic Aortic Valves: A Multicenter Study.

JACC. Cardiovascular interventions·2026
Same author

Aortic Valve Leaflet Modification: A Working Group Position Statement on Best Practices and Step-by-Step Guide.

JACC. Cardiovascular interventions·2026
Same author

Current Evidence, Emerging Evidence, and Decision-Making: An Algorithm for Leaflet Modification Procedures.

JACC. Cardiovascular interventions·2026
Same author

5-in-1 Transcatheter Mitral Valve Replacement With Ventricular and Atrial Septal Closure Using Electrosurgery.

JACC. Cardiovascular interventions·2026
Same author

Adapting Interventional Echocardiography to New Techniques: Echocardiographic Guidance for Transcatheter Myotomy Using Septal Scoring Along the Midline Endocardium.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography·2026
Same author

Beware the Unpredictability of Modified UNICORN.

JACC. Case reports·2026
Same journal

Double Transseptal Guide Sheath Technique to Prevent Low Dock Positioning During Transcatheter Mitral Valve Replacement.

JACC. Cardiovascular interventions·2026
Same journal

Real-World Outcomes of Dedicated Leaflet Modification for Bioprosthetic Valve-In-Valve TAVR: A 150-Patient Commercial Experience.

JACC. Cardiovascular interventions·2026
Same journal

Effect of Nominal-Volume ("Double Tap") Postdilatation on Significant THV Mid-Stent Frame Underexpansion After Balloon-Expandable TAVR.

JACC. Cardiovascular interventions·2026
Same journal

Redo-TAVR (TAV-in-TAV) Best Practices Part 2: Tall-in-Short and Tall-in-Tall - A Heart and Valve Collaboratory Document.

JACC. Cardiovascular interventions·2026
Same journal

Redo-TAVR (TAV-in-TAV) Best Practices Part 1: Short-in-Short and Short-in-Tall - A Heart and Valve Collaboratory Document.

JACC. Cardiovascular interventions·2026
Same journal

REPLY: The Angiographic Veto: Putting the Operator Back in DAPT De-Escalation.

JACC. Cardiovascular interventions·2026
See all related articles

Related Experiment Video

Updated: Jun 24, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

Mitral Valve Leaflet Modification: A Working Group Position Statement on Best Practices and Step-by-Step Guide.

James M McCabe1, Robert J Lederman2, David Elison3

  • 1Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA; Center for Innovation in Invasive Cardiology, Boston, Massachusetts, USA.

JACC. Cardiovascular Interventions
|June 22, 2026
PubMed
Summary
This summary is machine-generated.

Mitral leaflet modification techniques, like LAMPOON, prevent dangerous left ventricular outflow tract (LVOT) obstruction during transcatheter mitral valve replacement (TMVR). This guidance synthesizes international experience to improve operator proficiency and expand TMVR patient eligibility.

Keywords:
LAMPOONcomputed tomographyleaflet modificationleft ventricular outflow tract obstructiontranscatheter electrosurgerytranscatheter mitral valve replacement

More Related Videos

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
07:42

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

Published on: May 19, 2020

Related Experiment Videos

Last Updated: Jun 24, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
08:31

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair

Published on: October 16, 2021

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat
07:42

An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

Published on: May 19, 2020

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • Left ventricular outflow tract (LVOT) obstruction is a critical complication of transcatheter mitral valve replacement (TMVR).
  • Preprocedural cardiac computed tomography accurately identifies patients at risk for LVOT obstruction.
  • Mitral leaflet modification techniques, such as LAMPOON, are effective in preventing TMVR-induced LVOT obstruction.

Purpose of the Study:

  • To provide contemporary best-practice guidance for mitral leaflet modification.
  • To synthesize international experience and address barriers to adoption.
  • To improve operator proficiency and expand the treatable patient population for TMVR.

Main Methods:

  • Review of state-of-the-art techniques and international experience.
  • Detailed explanation of transcatheter electrosurgery principles.
  • Computed tomography-based risk analysis and procedural planning.
  • Step-by-step guide to the LAMPOON technique and management of challenges.

Main Results:

  • Mitral leaflet modification effectively prevents LVOT obstruction, expanding TMVR applicability.
  • Guidance addresses perceived technical complexity and lack of purpose-built devices.
  • Best practices aim to enhance operator proficiency in LAMPOON and related techniques.

Conclusions:

  • Contemporary best-practice guidance for mitral leaflet modification is crucial for safe and effective TMVR.
  • Standardized training and procedural techniques can overcome adoption barriers.
  • Improved proficiency in leaflet modification expands treatment options for patients with mitral valve disease.