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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
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PRAME Expression and Melanoma In Situ Margin Assessment.

Thomas N Helm1, Charlene Lam1, Bohdan Zoshchuk2

  • 1Departments of Dermatology, and.

The American Journal of Dermatopathology
|June 22, 2026
PubMed
Summary
This summary is machine-generated.

Determining melanoma in situ margins on sun-damaged skin is challenging. PRAME immunohistochemistry aids in identifying subclinical spread but doesn't fully resolve diagnostic difficulties for lentigo maligna melanoma in situ.

Keywords:
PRAMElentigolentigo malignamarginsmelanoma in situ

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Area of Science:

  • Dermatopathology
  • Oncology
  • Immunohistochemistry

Background:

  • Melanoma in situ on chronically sun-damaged skin can have subclinical extensions.
  • Accurate margin assessment is crucial for effective treatment of lentigo maligna.
  • Clinical visualization often underestimates the true extent of melanoma in situ.

Purpose of the Study:

  • To highlight the diagnostic challenges in determining margins for melanoma in situ.
  • To evaluate the utility of PRAME immunohistochemistry in assessing subclinical spread.
  • To present a case study of lentigo maligna-type melanoma in situ with margin difficulties.

Main Methods:

  • Utilized immunohistochemistry, specifically PRAME staining.
  • Analyzed a case of melanoma in situ of the lentigo maligna type.
  • Correlated clinical findings with histopathological assessment.

Main Results:

  • PRAME immunohistochemistry provided additional information regarding subclinical spread.
  • Despite PRAME use, determining definitive margins remained a diagnostic challenge.
  • The case illustrated limitations in current diagnostic tools for complex melanoma in situ cases.

Conclusions:

  • Accurate margin delineation for lentigo maligna-type melanoma in situ remains difficult.
  • PRAME immunohistochemistry is a valuable adjunct but not a definitive solution.
  • Further advancements are needed for precise margin assessment in challenging melanoma in situ cases.